Title |
Metabolic recoding of epigenetics in cancer
|
---|---|
Published in |
Cancer Communications, May 2018
|
DOI | 10.1186/s40880-018-0302-3 |
Pubmed ID | |
Authors |
Yi‐Ping Wang, Qun‐Ying Lei |
Abstract |
Dysregulation of metabolism allows tumor cells to generate needed building blocks as well as to modulate epigenetic marks to support cancer initiation and progression. Cancer-induced metabolic changes alter the epigenetic landscape, especially modifications on histones and DNA, thereby promoting malignant transformation, adaptation to inadequate nutrition, and metastasis. Recent advances in cancer metabolism shed light on how aberrations in metabolites and metabolic enzymes modify epigenetic programs. The metabolism-induced recoding of epigenetics in cancer depends strongly on nutrient availability for tumor cells. In this review, we focus on metabolic remodeling of epigenetics in cancer and examine potential mechanisms by which cancer cells integrate nutritional inputs into epigenetic modification. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 50% |
Canada | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 147 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 18% |
Researcher | 19 | 13% |
Student > Master | 17 | 12% |
Student > Bachelor | 17 | 12% |
Student > Postgraduate | 7 | 5% |
Other | 18 | 12% |
Unknown | 42 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 50 | 34% |
Medicine and Dentistry | 18 | 12% |
Agricultural and Biological Sciences | 12 | 8% |
Chemistry | 5 | 3% |
Immunology and Microbiology | 4 | 3% |
Other | 12 | 8% |
Unknown | 46 | 31% |