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Metabolic recoding of epigenetics in cancer

Overview of attention for article published in Cancer Communications, May 2018
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Title
Metabolic recoding of epigenetics in cancer
Published in
Cancer Communications, May 2018
DOI 10.1186/s40880-018-0302-3
Pubmed ID
Authors

Yi‐Ping Wang, Qun‐Ying Lei

Abstract

Dysregulation of metabolism allows tumor cells to generate needed building blocks as well as to modulate epigenetic marks to support cancer initiation and progression. Cancer-induced metabolic changes alter the epigenetic landscape, especially modifications on histones and DNA, thereby promoting malignant transformation, adaptation to inadequate nutrition, and metastasis. Recent advances in cancer metabolism shed light on how aberrations in metabolites and metabolic enzymes modify epigenetic programs. The metabolism-induced recoding of epigenetics in cancer depends strongly on nutrient availability for tumor cells. In this review, we focus on metabolic remodeling of epigenetics in cancer and examine potential mechanisms by which cancer cells integrate nutritional inputs into epigenetic modification.

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Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 147 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 18%
Researcher 19 13%
Student > Master 17 12%
Student > Bachelor 17 12%
Student > Postgraduate 7 5%
Other 18 12%
Unknown 42 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 50 34%
Medicine and Dentistry 18 12%
Agricultural and Biological Sciences 12 8%
Chemistry 5 3%
Immunology and Microbiology 4 3%
Other 12 8%
Unknown 46 31%