Title |
Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity
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Published in |
Genome Biology, October 2011
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DOI | 10.1186/gb-2011-12-10-r108 |
Pubmed ID | |
Authors |
Markus Rasmussen, Magnus Sundström, Hanna Göransson Kultima, Johan Botling, Patrick Micke, Helgi Birgisson, Bengt Glimelius, Anders Isaksson |
Abstract |
We describe a bioinformatic tool, Tumor Aberration Prediction Suite (TAPS), for the identification of allele-specific copy numbers in tumor samples using data from Affymetrix SNP arrays. It includes detailed visualization of genomic segment characteristics and iterative pattern recognition for copy number identification, and does not require patient-matched normal samples. TAPS can be used to identify chromosomal aberrations with high sensitivity even when the proportion of tumor cells is as low as 30%. Analysis of cancer samples indicates that TAPS is well suited to investigate samples with aneuploidy and tumor heterogeneity, which is commonly found in many types of solid tumors. |
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Geographical breakdown
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United Kingdom | 2 | 2% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 98 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 33 | 30% |
Student > Ph. D. Student | 32 | 29% |
Student > Master | 13 | 12% |
Student > Bachelor | 6 | 6% |
Student > Doctoral Student | 6 | 6% |
Other | 15 | 14% |
Unknown | 4 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 45 | 41% |
Biochemistry, Genetics and Molecular Biology | 29 | 27% |
Computer Science | 13 | 12% |
Medicine and Dentistry | 8 | 7% |
Mathematics | 4 | 4% |
Other | 2 | 2% |
Unknown | 8 | 7% |