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Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice

Overview of attention for article published in Veterinary Research, July 2015
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  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

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2 tweeters

Citations

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8 Dimensions

Readers on

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15 Mendeley
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Title
Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice
Published in
Veterinary Research, July 2015
DOI 10.1186/s13567-015-0211-2
Pubmed ID
Authors

Hiroyuki Okada, Kentaro Masujin, Kohtaro Miyazawa, Takashi Yokoyama

Abstract

L-type bovine spongiform encephalopathy (L-BSE) is an atypical form of BSE that is transmissible to cattle and several lines of prion protein (PrP) transgenic mice, but not to wild-type mice. In this study, we examined the transmissibility of sheep-passaged L-BSE prions to wild-type mice. Disease-associated prion protein (PrP(Sc)) was detected in the brain and/or lymphoid tissues during the lifespan of mice that were asymptomatic subclinical carriers, indicating that wild-type mice were susceptible to sheep-passaged L-BSE. The morphological characteristics of the PrP(Sc) of sheep-passaged L-BSE included florid plaques that were distributed mainly in the cerebral cortex and hippocampus of subsequent passaged mice. The PrP(Sc) glycoform profiles of wild-type mice infected with sheep-passaged L-BSE were similar to those of the original isolate. The data indicate that sheep-passaged L-BSE has an altered host range and acquired transmissibility to wild-type mice.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 40%
Student > Ph. D. Student 3 20%
Student > Doctoral Student 1 7%
Student > Bachelor 1 7%
Other 1 7%
Other 3 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 33%
Agricultural and Biological Sciences 4 27%
Veterinary Science and Veterinary Medicine 2 13%
Environmental Science 1 7%
Arts and Humanities 1 7%
Other 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2015.
All research outputs
#2,495,344
of 5,407,015 outputs
Outputs from Veterinary Research
#226
of 496 outputs
Outputs of similar age
#85,094
of 186,931 outputs
Outputs of similar age from Veterinary Research
#10
of 29 outputs
Altmetric has tracked 5,407,015 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 496 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,931 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.