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Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors

Overview of attention for article published in BMC Cancer, July 2015
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Title
Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors
Published in
BMC Cancer, July 2015
DOI 10.1186/s12885-015-1530-4
Pubmed ID
Authors

Tomasz Wrzesiński, Malgorzata Szelag, Wojciech A. Cieślikowski, Agnieszka Ida, Rachel Giles, Elżbieta Zodro, Joanna Szumska, Joanna Poźniak, Zbigniew Kwias, Hans A.R. Bluyssen, Joanna Wesoly

Abstract

VHL inactivation is the most established molecular characteristic of clear cell renal cell carcinoma (ccRCC), with only a few additional genes implicated in development of this kidney tumor. In recently published ccRCC gene expression meta-analysis study we identified a number of deregulated genes with limited information available concerning their biological role, represented by gene transcripts belonging to transmembrane proteins family (TMEMs). TMEMs are predicted to be components of cellular membranes, such as mitochondrial membranes, ER, lysosomes and Golgi apparatus. Interestingly, the function of majority of TMEMs remains unclear. Here, we analyzed expression of ten TMEM genes in the context of ccRCC progression and development, and characterized these proteins bioinformatically. The expression of ten TMEMs (RTP3, SLC35G2, TMEM30B, TMEM45A, TMEM45B, TMEM61, TMEM72, TMEM116, TMEM207 and TMEM213) was measured by qPCR. T-test, Pearson correlation, univariate and multivariate logistic and Cox regression were used in statistical analysis. The topology of studied proteins was predicted with Metaserver, together with PSORTII, Pfam and Localizome tools. We observed significant deregulation of expression of 10 analyzed TMEMs in ccRCC tumors. Cluster analysis of expression data suggested the down-regulation of all tested TMEMs to be a descriptor of the most advanced tumors. Logistic and Cox regression potentially linked TMEM expression to clinical parameters such as: metastasis, Fuhrman grade and overall survival. Topology predictions classified majority of analyzed TMEMs as type 3 and type 1 transmembrane proteins, with predicted localization mainly in ER. The massive down-regulation of expression of TMEM family members suggests their importance in the pathogenesis of ccRCC and the bioinformatic analysis of TMEM topology implies a significant involvement of ER proteins in ccRCC pathology.

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Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 2 4%
Unknown 46 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 21%
Student > Ph. D. Student 9 19%
Student > Bachelor 5 10%
Researcher 5 10%
Student > Doctoral Student 4 8%
Other 8 17%
Unknown 7 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 35%
Agricultural and Biological Sciences 9 19%
Medicine and Dentistry 5 10%
Chemistry 3 6%
Social Sciences 2 4%
Other 4 8%
Unknown 8 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2015.
All research outputs
#3,541,842
of 5,347,972 outputs
Outputs from BMC Cancer
#1,551
of 2,788 outputs
Outputs of similar age
#120,608
of 185,835 outputs
Outputs of similar age from BMC Cancer
#102
of 152 outputs
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