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Broad protection with an inactivated vaccine against primary-isolated lethal enterovirus 71 infection in newborn mice

Overview of attention for article published in BMC Microbiology, July 2015
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Title
Broad protection with an inactivated vaccine against primary-isolated lethal enterovirus 71 infection in newborn mice
Published in
BMC Microbiology, July 2015
DOI 10.1186/s12866-015-0474-9
Pubmed ID
Authors

Junliang Chang, Jingliang Li, Xin Liu, Guanchen Liu, Jiaxin Yang, Wei, Wenyan Zhang, Xiao-Fang Yu

Abstract

Circulating enterovirus 71 (EV-A71)-associated hand, foot, and mouth disease is on the rise in the Asian-Pacific region. Although animal models have been developed using mouse-adapted EV-A71 strains, mouse models using primary EV-A71 isolates are scarce. Lethal animal models with circulating EV-A71 infection would contribute to studies of pathogenesis as well as vaccine development and evaluation. In this study, we established a lethal mouse model using primary EV-A71 isolates from patients infected with serotypes that are currently circulating in humans. We also characterized the dose-dependent virulence and pathologic changes of circulating EV-A71 in this mouse model. Most importantly, we have established this mouse model as a suitable system for EV-A71 vaccine evaluation. An inactivated EV-A71 vaccine candidate offered complete protection from death induced by various circulating EV-A71 viruses to neonatal mice that were born to immunized female mice. The sera of the immunized dams and their pups showed higher neutralization titers against multiple circulating EV-A71 viruses. Thus, our newly established animal model using primary EV-A71 isolates is helpful for future studies on viral pathogenesis and vaccine and drug development.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 33%
Student > Bachelor 4 19%
Other 2 10%
Student > Ph. D. Student 1 5%
Student > Master 1 5%
Other 2 10%
Unknown 4 19%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Biochemistry, Genetics and Molecular Biology 2 10%
Agricultural and Biological Sciences 2 10%
Decision Sciences 1 5%
Computer Science 1 5%
Other 4 19%
Unknown 5 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2015.
All research outputs
#4,459,253
of 5,357,318 outputs
Outputs from BMC Microbiology
#891
of 1,094 outputs
Outputs of similar age
#149,354
of 185,372 outputs
Outputs of similar age from BMC Microbiology
#40
of 45 outputs
Altmetric has tracked 5,357,318 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,094 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.