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Functional roles of DExD/H-box RNA helicases in Pre-mRNA splicing

Overview of attention for article published in Journal of Biomedical Science, July 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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Title
Functional roles of DExD/H-box RNA helicases in Pre-mRNA splicing
Published in
Journal of Biomedical Science, July 2015
DOI 10.1186/s12929-015-0161-z
Pubmed ID
Authors

Yen-Chi Liu, Soo-Chen Cheng

Abstract

Splicing of precursor mRNA takes place via two consecutive steps of transesterification catalyzed by a large ribonucleoprotein complex called the spliceosome. The spliceosome is assembled through ordered binding to the pre-mRNA of five small nuclear RNAs and numerous protein factors, and is disassembled after completion of the reaction to recycle all components. Throughout the splicing cycle, the spliceosome changes its structure, rearranging RNA-RNA, RNA-protein and protein-protein interactions, for positioning and repositioning of splice sites. DExD/H-box RNA helicases play important roles in mediating structural changes of the spliceosome by unwinding of RNA duplexes or disrupting RNA-protein interactions. DExD/H-box proteins are also implicated in the fidelity control of the splicing process at various steps. This review summarizes the functional roles of DExD/H-box proteins in pre-mRNA splicing according to studies conducted mostly in yeast and will discuss the concept of the complicated splicing reaction based on recent findings.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 103 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 30%
Student > Master 14 13%
Researcher 13 13%
Student > Bachelor 11 11%
Other 5 5%
Other 12 12%
Unknown 18 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 46 44%
Agricultural and Biological Sciences 29 28%
Chemistry 4 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 <1%
Mathematics 1 <1%
Other 4 4%
Unknown 19 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2015.
All research outputs
#15,090,466
of 25,373,627 outputs
Outputs from Journal of Biomedical Science
#637
of 1,101 outputs
Outputs of similar age
#132,877
of 276,290 outputs
Outputs of similar age from Journal of Biomedical Science
#10
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,101 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,290 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.