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Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

Overview of attention for article published in Cancer Cell International, July 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#26 of 1,598)
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

news
1 news outlet
twitter
4 tweeters
facebook
1 Facebook page
wikipedia
10 Wikipedia pages

Citations

dimensions_citation
313 Dimensions

Readers on

mendeley
538 Mendeley
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Title
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
Published in
Cancer Cell International, July 2015
DOI 10.1186/s12935-015-0221-1
Pubmed ID
Authors

Khalid O Alfarouk, Christian-Martin Stock, Sophie Taylor, Megan Walsh, Abdel Khalig Muddathir, Daniel Verduzco, Adil H H Bashir, Osama Y Mohammed, Gamal O Elhassan, Salvador Harguindey, Stephan J Reshkin, Muntaser E Ibrahim, Cyril Rauch

Abstract

Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemotherapy resistance can arise due to several host or tumor-related factors. However, most current research is focused on tumor-specific factors and specifically genes that handle expression of pumps that efflux accumulated drugs inside malignantly transformed types of cells. In this work, we suggest a wider and alternative perspective that sets the stage for a future platform in modifying drug resistance with respect to the treatment of cancer.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 538 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 <1%
France 1 <1%
India 1 <1%
United Kingdom 1 <1%
Iran, Islamic Republic of 1 <1%
United States 1 <1%
Unknown 532 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 87 16%
Student > Ph. D. Student 81 15%
Student > Bachelor 81 15%
Researcher 43 8%
Student > Doctoral Student 27 5%
Other 76 14%
Unknown 143 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 122 23%
Pharmacology, Toxicology and Pharmaceutical Science 53 10%
Medicine and Dentistry 48 9%
Agricultural and Biological Sciences 48 9%
Chemistry 37 7%
Other 71 13%
Unknown 159 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2022.
All research outputs
#1,956,963
of 21,585,719 outputs
Outputs from Cancer Cell International
#26
of 1,598 outputs
Outputs of similar age
#26,317
of 244,846 outputs
Outputs of similar age from Cancer Cell International
#1
of 1 outputs
Altmetric has tracked 21,585,719 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,598 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,846 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them