Title |
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
|
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Published in |
Cancer Cell International, July 2015
|
DOI | 10.1186/s12935-015-0221-1 |
Pubmed ID | |
Authors |
Khalid O Alfarouk, Christian-Martin Stock, Sophie Taylor, Megan Walsh, Abdel Khalig Muddathir, Daniel Verduzco, Adil H H Bashir, Osama Y Mohammed, Gamal O Elhassan, Salvador Harguindey, Stephan J Reshkin, Muntaser E Ibrahim, Cyril Rauch |
Abstract |
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemotherapy resistance can arise due to several host or tumor-related factors. However, most current research is focused on tumor-specific factors and specifically genes that handle expression of pumps that efflux accumulated drugs inside malignantly transformed types of cells. In this work, we suggest a wider and alternative perspective that sets the stage for a future platform in modifying drug resistance with respect to the treatment of cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 2 | 50% |
Members of the public | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
France | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
United States | 1 | <1% |
Unknown | 696 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 103 | 15% |
Student > Master | 96 | 14% |
Student > Bachelor | 90 | 13% |
Researcher | 51 | 7% |
Student > Doctoral Student | 32 | 5% |
Other | 84 | 12% |
Unknown | 246 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 152 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 59 | 8% |
Medicine and Dentistry | 53 | 8% |
Agricultural and Biological Sciences | 50 | 7% |
Chemistry | 49 | 7% |
Other | 72 | 10% |
Unknown | 267 | 38% |