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Mendeley readers
Attention Score in Context
| Title |
Autophagy Impairment in a Mouse Model of Neuropathic Pain
|
|---|---|
| Published in |
Molecular Pain, January 2011
|
| DOI | 10.1186/1744-8069-7-83 |
| Pubmed ID | |
| Authors |
Laura Berliocchi, Rossella Russo, Maria Maiarù, Alessandra Levato, Giacinto Bagetta, Maria Tiziana Corasaniti |
| Abstract |
Autophagy is an intracellular membrane trafficking pathway controlling the delivery of cytoplasmic material to the lysosomes for degradation. It plays an important role in cell homeostasis in both normal settings and abnormal, stressful conditions. It is now recognised that an imbalance in the autophagic process can impact basal cell functions and this has recently been implicated in several human diseases, including neurodegeneration and cancer.Here, we investigated the consequences of nerve injury on the autophagic process in a commonly used model of neuropathic pain. The expression and modulation of the main autophagic marker, the microtubule-associated protein 1 light chain 3 (LC3), was evaluated in the L4-L5 cord segment seven days after spinal nerve ligation (SNL). Levels of LC3-II, the autophagosome-associated LC3 form, were markedly higher in the spinal cord ipsilateral to the ligation side, appeared to correlate with the upregulation of the calcium channel subunit α2δ-1 and were not present in mice that underwent sham surgery. However, LC3-I and Beclin 1 expression were only slightly increased. On the contrary, SNL promoted the accumulation of the ubiquitin- and LC3-binding protein p62, which inversely correlates with autophagic activity, thus pointing to a block of autophagosome turnover.Our data showed for the first time that basal autophagy is disrupted in a model of neuropathic pain. |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 47 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 15% |
| Student > Ph. D. Student | 6 | 13% |
| Student > Postgraduate | 5 | 10% |
| Other | 5 | 10% |
| Student > Bachelor | 4 | 8% |
| Other | 11 | 23% |
| Unknown | 10 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 21% |
| Medicine and Dentistry | 10 | 21% |
| Agricultural and Biological Sciences | 8 | 17% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 12 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2021.
All research outputs
#8,261,756
of 25,373,627 outputs
Outputs from Molecular Pain
#178
of 669 outputs
Outputs of similar age
#56,318
of 190,474 outputs
Outputs of similar age from Molecular Pain
#11
of 36 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.