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Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria

Overview of attention for article published in Malaria Journal, July 2015
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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3 X users
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1 Wikipedia page

Citations

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4 Dimensions

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46 Mendeley
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Title
Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria
Published in
Malaria Journal, July 2015
DOI 10.1186/s12936-015-0799-8
Pubmed ID
Authors

Cyril Badaut, Léa Guyonnet, Jacqueline Milet, Emmanuelle Renard, Rémy Durand, Firmine Viwami, Gratien Sagbo, Francis Layla, Philippe Deloron, Serge Bonnefoy, Florence Migot-Nabias

Abstract

The three members of the ring-infected erythrocyte surface antigen (RESA) proteins family share high sequence homologies, which impair the detection and assignment to one or another protein of some pathogenic processes inherent to Plasmodium falciparum malaria. The present study was intended to determine if the antibody and inflammatory responses of children living in a malaria-endemic area varied depending on the RESA-1, RESA-2 or RESA-3 proteins and the severity of the disease, two groups of severe and uncomplicated malaria cases being considered. Two synthetic peptides representing predicted B cell epitopes were designed per RESA protein, all located outside of the 3' and 5' repetition blocks, in order to allow an antibody detection specific of each member of the family. Recombinant rRESA-1B and rRESA-3B proteins were also engineered. Two groups of Beninese children admitted to hospital in 2009 for either uncomplicated or severe malaria were compared for their plasma levels of IgG specifically recognizing each recombinant RESA protein or synthetic peptide, and for their plasma inflammatory cytokine levels (IFN-γ, TNF-α and IL-10), taking into account host and parasite genetic factors. The absence of IgG cross-reactivity between rRESA proteins and their protein carrier as well as between each RESA peptide and a non-epitopic RESA control peptide validated the use of the engineered recombinant proteins and peptides for the measurement of plasma IgG. Taking into account age, fever duration and parasitaemia, a multiple logistic regression performed on children clustered according to their antibody responses' profiles concluded to an increased risk of severe malaria for P2 (representative of RESA-1) responders (P = 0.007). Increased IL-10 plasma levels were found in children harbouring multiclonal P. falciparum infections on the basis of the T1526G resa2 gene polymorphism (P = 0.004). This study provided novel tools to dissect the seroreactivity against the three members of the RESA protein family and to describe its relation to protection against malaria. It suggested the measurement of plasma antibodies raised against specific peptides to serve as predictive immunologic markers for disease severity. Lastly, it reinforced previous observations linking the T1526G resa2 gene mutation to severe malaria.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Student > Master 7 15%
Student > Bachelor 6 13%
Researcher 6 13%
Student > Postgraduate 3 7%
Other 5 11%
Unknown 10 22%
Readers by discipline Count As %
Medicine and Dentistry 12 26%
Biochemistry, Genetics and Molecular Biology 7 15%
Agricultural and Biological Sciences 6 13%
Computer Science 3 7%
Immunology and Microbiology 3 7%
Other 7 15%
Unknown 8 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2019.
All research outputs
#6,421,645
of 22,817,213 outputs
Outputs from Malaria Journal
#1,855
of 5,563 outputs
Outputs of similar age
#74,992
of 262,407 outputs
Outputs of similar age from Malaria Journal
#41
of 105 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 5,563 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,407 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.