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Regulation of density of functional presynaptic terminals by local energy supply

Overview of attention for article published in Molecular Brain, July 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#10 of 1,053)
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

news
10 news outlets
twitter
2 tweeters
patent
1 patent

Citations

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10 Dimensions

Readers on

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25 Mendeley
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Title
Regulation of density of functional presynaptic terminals by local energy supply
Published in
Molecular Brain, July 2015
DOI 10.1186/s13041-015-0132-z
Pubmed ID
Authors

Hang Zhou, Guosong Liu

Abstract

The density of functional synapses is an important parameter in determining the efficacy of synaptic transmission. However, how functional presynaptic terminal density is regulated under natural physiological conditions is still poorly understood. We studied the factors controlling the density of presynaptic functional terminals at single dendritic branches of hippocampal neurons and found that elevation of intracellular Mg(2+) concentration was effective in increasing the density of functional terminals. Interestingly, the upregulation was not due to synaptogenesis, but to the conversion of a considerable proportion of presynaptic terminals from nonfunctional to functional. Mechanistic studies revealed that the nonfunctional terminals had inadequate Ca(2+)-sensitivity-related proteins, resulting in very low Ca(2+) sensitivity within their vesicle release machinery. We identified energy-dependent axonal transport as a primary factor controlling the amount of Ca(2+)-sensitivity-related proteins in terminals. The elevation of intracellular Mg(2+) enhanced local energy supply and promoted the increase of Ca(2+)-sensitivity-related proteins in terminals, leading to increased functional terminal density. Our study suggests that local energy supply plays a critical role in controlling the density of functional presynaptic terminals, demonstrating the link between energy supply and efficacy of synaptic transmission.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 32%
Researcher 4 16%
Student > Bachelor 3 12%
Other 3 12%
Student > Master 3 12%
Other 1 4%
Unknown 3 12%
Readers by discipline Count As %
Neuroscience 7 28%
Agricultural and Biological Sciences 6 24%
Engineering 2 8%
Medicine and Dentistry 2 8%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 2 8%
Unknown 5 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 76. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2022.
All research outputs
#422,833
of 21,287,234 outputs
Outputs from Molecular Brain
#10
of 1,053 outputs
Outputs of similar age
#4,431
of 194,294 outputs
Outputs of similar age from Molecular Brain
#1
of 1 outputs
Altmetric has tracked 21,287,234 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,053 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,294 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them