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The opposite roles of PAS-5 and Galectin-1 in immune response during the early infection of Angiostrongylus cantonensis

Overview of attention for article published in Parasites & Vectors, May 2018
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Title
The opposite roles of PAS-5 and Galectin-1 in immune response during the early infection of Angiostrongylus cantonensis
Published in
Parasites & Vectors, May 2018
DOI 10.1186/s13071-018-2894-5
Pubmed ID
Authors

Lan-Zhu Yan, Xiao-Meng Shi, Yan-Wen Zu, Yuan-Yuan Shen, Xi-Xi Chen, Meng-Jing Zhao, Xing-Pan Li, Bao-Long Yan, Hui-Cong Huang

Abstract

Angiostrongylus cantonensis is a human zoonotic nematode parasite. Our previous studies found that PAS-5 and Galectin-1 (Gal-1) proteins of A. cantonensis could be strongly recognized by sera from mice infected with A. cantonensis. In this study, we further evaluated the potential roles of these two proteins in the induction of immune response in mice. Mice were immunized with recombinant PAS-5 or Gal-1 and then challenged with 30 infective A. cantonensis larvae following the last immunization. We then examined the infected mice for changes in serum antibodies and cytokines by ELISA, CD4+ T cells and CD4+CD25+FoxP3+ regulatory T cells (Tregs) by flow cytometry, and tissue damage severity by hematoxylin-eosin (H&E) staining. Compared with control mice, the PAS-5-immunized mice exhibited increased levels of serum antibodies and cytokines (except for IL-10) at different time points post-infection. PAS-5 immunization promoted significant proliferation of CD4+ T cells, and caused more damage in the brain tissue. Vaccination with Gal-1 inhibited the production of antibodies (except for IgG1) and IFN-γ, but promoted the expression of IL-4 and IL-10. Gal-1 immunization results in significant increases in the levels of CD4+CD25+FoxP3+ Tregs, and mild inflammatory changes. Taken together, our findings show that PAS-5 enhances, but Gal-1 inhibits the immune response in the early stage of A. cantonensis infections.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 18%
Lecturer 1 9%
Student > Doctoral Student 1 9%
Student > Bachelor 1 9%
Student > Master 1 9%
Other 1 9%
Unknown 4 36%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 1 9%
Biochemistry, Genetics and Molecular Biology 1 9%
Nursing and Health Professions 1 9%
Immunology and Microbiology 1 9%
Unknown 7 64%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2018.
All research outputs
#9,958,462
of 13,017,042 outputs
Outputs from Parasites & Vectors
#2,220
of 3,439 outputs
Outputs of similar age
#187,980
of 271,585 outputs
Outputs of similar age from Parasites & Vectors
#1
of 2 outputs
Altmetric has tracked 13,017,042 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,439 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
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