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DNA loops and semicatenated DNA junctions

Overview of attention for article published in BMC Molecular and Cell Biology, July 2000
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)

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Title
DNA loops and semicatenated DNA junctions
Published in
BMC Molecular and Cell Biology, July 2000
DOI 10.1186/1471-2091-1-1
Pubmed ID
Authors

Claire Gaillard, François Strauss

Abstract

Alternative DNA conformations are of particular interest as potential signals to mark important sites on the genome. The structural variability of CA microsatellites is particularly pronounced; these are repetitive poly(CA). poly(TG) DNA sequences spread in all eukaryotic genomes as tracts of up to 60 base pairs long. Many in vitro studies have shown that the structure of poly(CA). poly(TG) can vary markedly from the classical right handed DNA double helix and adopt diverse alternative conformations. Here we have studied the mechanism of formation and the structure of an alternative DNA structure, named Form X, which was observed previously by polyacrylamide gel electrophoresis of DNA fragments containing a tract of the CA microsatellite poly(CA). poly(TG) but had not yet been characterized. Formation of Form X was found to occur upon reassociation of the strands of a DNA fragment containing a tract of poly(CA). poly(TG), in a process strongly stimulated by the nuclear proteins HMG1 and HMG2. By inserting Form X into DNA minicircles, we show that the DNA strands do not run fully side by side but instead form a DNA knot. When present in a closed DNA molecule, Form X becomes resistant to heating to 100 degrees C and to alkaline pH. Our data strongly support a model of Form X consisting in a DNA loop at the base of which the two DNA duplexes cross, with one of the strands of one duplex passing between the strands of the other duplex, and reciprocally, to form a semicatenated DNA junction also called a DNA hemicatenane.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 27%
Student > Master 3 14%
Librarian 1 5%
Student > Bachelor 1 5%
Lecturer 1 5%
Other 2 9%
Unknown 8 36%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 23%
Computer Science 4 18%
Medicine and Dentistry 2 9%
Biochemistry, Genetics and Molecular Biology 1 5%
Immunology and Microbiology 1 5%
Other 1 5%
Unknown 8 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2015.
All research outputs
#4,216,101
of 25,373,627 outputs
Outputs from BMC Molecular and Cell Biology
#80
of 1,233 outputs
Outputs of similar age
#5,264
of 39,052 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#1
of 1 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 39,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them