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Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli

Overview of attention for article published in Molecular Autism, May 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#15 of 720)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

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6 news outlets
blogs
1 blog
twitter
286 X users
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6 Facebook pages

Citations

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72 Dimensions

Readers on

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228 Mendeley
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Title
Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli
Published in
Molecular Autism, May 2018
DOI 10.1186/s13229-018-0218-4
Pubmed ID
Authors

Stephen Bent, Brittany Lawton, Tracy Warren, Felicia Widjaja, Katherine Dang, Jed W. Fahey, Brian Cornblatt, Jason M. Kinchen, Kevin Delucchi, Robert L. Hendren

Abstract

Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterations. Sulforaphane, a supplement with indirect antioxidant effects that are derived from broccoli sprouts and seeds, was recently shown to lead to improvements in behavior and social responsiveness in children with ASD. We conducted the current open-label study to determine if we could identify changes in urinary metabolites that were associated with clinical improvements with the goal of identifying a potential mechanism of action. Children and young adults enrolled in a school for children with ASD and related neurodevelopmental disorders were recruited to participate in a 12-week, open-label study of sulforaphane. Fasting urinary metabolites and measures of behavior (Aberrant Behavior Checklist-ABC) and social responsiveness (Social Responsiveness Scale-SRS) were measured at baseline and at the end of the study. Pearson's correlation coefficient was calculated for the pre- to post-intervention change in each of the two clinical scales (ABS and SRS) versus the change in each metabolite. Fifteen children completed the 12-week study. Mean scores on both symptom measures showed improvements (decreases) over the study period, but only the change in the SRS was significant. The ABC improved - 7.1 points (95% CI - 17.4 to 3.2), and the SRS improved - 9.7 points (95% CI - 18.7 to - 0.8). We identified 77 urinary metabolites that were correlated with changes in symptoms, and they clustered into pathways of oxidative stress, amino acid/gut microbiome, neurotransmitters, hormones, and sphingomyelin metabolism. Urinary metabolomics analysis is a useful tool to identify pathways that may be involved in the mechanism of action of treatments targeting abnormal physiology in ASD. This study was prospectively registered at clinicaltrials.gov (NCT02654743) on January 11, 2016.

X Demographics

X Demographics

The data shown below were collected from the profiles of 286 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 228 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 29 13%
Student > Master 28 12%
Student > Bachelor 24 11%
Student > Ph. D. Student 15 7%
Other 14 6%
Other 33 14%
Unknown 85 37%
Readers by discipline Count As %
Medicine and Dentistry 38 17%
Nursing and Health Professions 15 7%
Biochemistry, Genetics and Molecular Biology 13 6%
Agricultural and Biological Sciences 13 6%
Psychology 12 5%
Other 39 17%
Unknown 98 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 241. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2023.
All research outputs
#156,959
of 25,563,770 outputs
Outputs from Molecular Autism
#15
of 720 outputs
Outputs of similar age
#3,468
of 344,723 outputs
Outputs of similar age from Molecular Autism
#4
of 14 outputs
Altmetric has tracked 25,563,770 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 720 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,723 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.