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Mendeley readers
Attention Score in Context
| Title |
Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment
|
|---|---|
| Published in |
Arthritis Research & Therapy, July 2010
|
| DOI | 10.1186/ar3065 |
| Pubmed ID | |
| Authors |
Constanze Buhrmann, Ali Mobasheri, Ulrike Matis, Mehdi Shakibaei |
| Abstract |
Osteoarthritis (OA) and rheumatoid arthritis (RA) are characterised by joint inflammation and cartilage degradation. Although mesenchymal stem cell (MSC)-like progenitors are resident in the superficial zone of articular cartilage, damaged tissue does not possess the capacity for regeneration. The high levels of pro-inflammatory cytokines present in OA/RA joints may impede the chondrogenic differentiation of these progenitors. Interleukin (IL)-1β activates the transcription factor nuclear factor-κB (NF-κB), which in turn activates proteins involved in matrix degradation, inflammation and apoptosis. Curcumin is a phytochemical capable of inhibiting IL-1β-induced activation of NF-κB and expression of apoptotic and pro-inflammatory genes in chondrocytes. Therefore, the aim of the present study was to evaluate the influence of curcumin on IL-1β-induced NF-κB signalling pathway in MSCs during chondrogenic differentiation. |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 138 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 20% |
| Researcher | 23 | 16% |
| Student > Master | 17 | 12% |
| Student > Bachelor | 17 | 12% |
| Professor | 9 | 6% |
| Other | 18 | 13% |
| Unknown | 29 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 24% |
| Agricultural and Biological Sciences | 30 | 21% |
| Biochemistry, Genetics and Molecular Biology | 15 | 11% |
| Engineering | 6 | 4% |
| Nursing and Health Professions | 5 | 4% |
| Other | 20 | 14% |
| Unknown | 32 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2015.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#1,710
of 3,381 outputs
Outputs of similar age
#37,923
of 103,849 outputs
Outputs of similar age from Arthritis Research & Therapy
#16
of 32 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,849 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.