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The level of lipopolysaccharide-binding protein is elevated in adult patients with obstructive sleep apnea

Overview of attention for article published in BMC Pulmonary Medicine, May 2018
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Title
The level of lipopolysaccharide-binding protein is elevated in adult patients with obstructive sleep apnea
Published in
BMC Pulmonary Medicine, May 2018
DOI 10.1186/s12890-018-0647-z
Pubmed ID
Authors

Yinfeng Kong, Zhijun Li, Tingyu Tang, Haiyan Wu, Juan Liu, Liang Gu, Tian Zhao, Qingdong Huang

Abstract

lipopolysaccharide-binding protein (LBP) has been to be a surrogate marker of inflammation in OSA. This study aimed to test the hypothesis that the concentration of LBP is elevated in adult patients with obstructive sleep apnea (OSA). A total of 90 patients were enrolled into the study, 50 subjects were divided into OSA groups and 40 in healthy control according to PSG examination. Subsequently, patients with apnea-hypopnea index (AHI) ≧ 5, were divided into different subgroups according to blood pressure, gender, body mass index (BMI) and AHI. Venous blood samples were collected for detection after polysomnography. The serum levels of LBP and proinflammatory cytokines (interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α) were tested by ELISA. The present study demonstrated that the serum levels of both LBP and proinflammatory cytokines were elevated in OSA patients. A stratified analysis conducted to analyze differences among subgroups indicated that OSA patients with a higher AHI or BMI had an increased level of LBP and proinflammatory cytokines (all p < 0.05). Furthermore, a significant correlations were observed between LBP and inflammation and AHI. Multivariate regression analysis also demonstrated that AHI, LSaO2 and BMI had impact on the concentration of LBP. The research showed that the serum level of LBP and proinflammatory cytokines were elevated in adult patients with OSA, and an association with severity of disease and BMI were established. Furthermore, sleep apnea and BMI had effect on the concentration of LBP.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 22%
Student > Master 2 11%
Other 1 6%
Student > Doctoral Student 1 6%
Lecturer 1 6%
Other 2 11%
Unknown 7 39%
Readers by discipline Count As %
Medicine and Dentistry 3 17%
Nursing and Health Professions 2 11%
Neuroscience 2 11%
Psychology 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 2 11%
Unknown 7 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2018.
All research outputs
#9,958,421
of 13,017,042 outputs
Outputs from BMC Pulmonary Medicine
#650
of 1,029 outputs
Outputs of similar age
#187,920
of 271,585 outputs
Outputs of similar age from BMC Pulmonary Medicine
#1
of 1 outputs
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