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Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

Overview of attention for article published in Nutrition & Metabolism, October 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#16 of 1,020)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
7 news outlets
blogs
2 blogs
twitter
347 X users
facebook
86 Facebook pages
wikipedia
3 Wikipedia pages
googleplus
20 Google+ users
reddit
6 Redditors
video
1 YouTube creator

Citations

dimensions_citation
173 Dimensions

Readers on

mendeley
442 Mendeley
citeulike
1 CiteULike
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Title
Is there a role for carbohydrate restriction in the treatment and prevention of cancer?
Published in
Nutrition & Metabolism, October 2011
DOI 10.1186/1743-7075-8-75
Pubmed ID
Authors

Rainer J Klement, Ulrike Kämmerer

Abstract

Over the last years, evidence has accumulated suggesting that by systematically reducing the amount of dietary carbohydrates (CHOs) one could suppress, or at least delay, the emergence of cancer, and that proliferation of already existing tumor cells could be slowed down. This hypothesis is supported by the association between modern chronic diseases like the metabolic syndrome and the risk of developing or dying from cancer. CHOs or glucose, to which more complex carbohydrates are ultimately digested, can have direct and indirect effects on tumor cell proliferation: first, contrary to normal cells, most malignant cells depend on steady glucose availability in the blood for their energy and biomass generating demands and are not able to metabolize significant amounts of fatty acids or ketone bodies due to mitochondrial dysfunction. Second, high insulin and insulin-like growth factor (IGF)-1 levels resulting from chronic ingestion of CHO-rich Western diet meals, can directly promote tumor cell proliferation via the insulin/IGF1 signaling pathway. Third, ketone bodies that are elevated when insulin and blood glucose levels are low, have been found to negatively affect proliferation of different malignant cells in vitro or not to be usable by tumor cells for metabolic demands, and a multitude of mouse models have shown anti-tumorigenic properties of very low CHO ketogenic diets. In addition, many cancer patients exhibit an altered glucose metabolism characterized by insulin resistance and may profit from an increased protein and fat intake.In this review, we address the possible beneficial effects of low CHO diets on cancer prevention and treatment. Emphasis will be placed on the role of insulin and IGF1 signaling in tumorigenesis as well as altered dietary needs of cancer patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 347 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 442 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 2%
United Kingdom 4 <1%
Netherlands 2 <1%
Germany 2 <1%
Australia 2 <1%
Brazil 2 <1%
Chile 1 <1%
Italy 1 <1%
Denmark 1 <1%
Other 3 <1%
Unknown 417 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 72 16%
Student > Master 71 16%
Researcher 59 13%
Other 43 10%
Student > Ph. D. Student 40 9%
Other 89 20%
Unknown 68 15%
Readers by discipline Count As %
Medicine and Dentistry 137 31%
Agricultural and Biological Sciences 82 19%
Biochemistry, Genetics and Molecular Biology 36 8%
Nursing and Health Professions 35 8%
Sports and Recreations 12 3%
Other 59 13%
Unknown 81 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 398. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2024.
All research outputs
#76,340
of 25,559,053 outputs
Outputs from Nutrition & Metabolism
#16
of 1,020 outputs
Outputs of similar age
#221
of 152,748 outputs
Outputs of similar age from Nutrition & Metabolism
#2
of 19 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,020 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,748 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.