Title |
Associations of SNPs located at candidate genes to bovine growth traits, prioritized with an interaction networks construction approach
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Published in |
BMC Genomic Data, July 2015
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DOI | 10.1186/s12863-015-0247-3 |
Pubmed ID | |
Authors |
Francisco Alejandro Paredes-Sánchez, Ana María Sifuentes-Rincón, Aldo Segura Cabrera, Carlos Armando García Pérez, Gaspar Manuel Parra Bracamonte, Pascuala Ambriz Morales |
Abstract |
For most domestic animal species, including bovines, it is difficult to identify causative genetic variants involved in economically relevant traits. The candidate gene approach is efficient because it investigates genes that are expected to be associated with the expression of a trait and defines whether the genetic variation present in a population is associated with phenotypic diversity. A potential limitation of this approach is the identification of candidates. This study used a bioinformatics approach to identify candidate genes via a search guided by a functional interaction network. A functional interaction network tool, BosNet, was constructed for Bos taurus. Predictions for candidate genes were performed using the guilt-by-association principle in BosNet. Association analyses identified five novel markers within BosNet-prioritized genes that had significant effects on different growth traits in Charolais and Brahman cattle. BosNet is an excellent tool for the identification of single nucleotide polymorphisms that are potentially associated with complex traits. |
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Mendeley readers
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Readers by professional status | Count | As % |
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Researcher | 4 | 20% |
Student > Master | 4 | 20% |
Student > Doctoral Student | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Professor | 1 | 5% |
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Unknown | 5 | 25% |