Title |
In-field and abscopal response after short-course radiation therapy in patients with metastatic Merkel cell carcinoma progressing on PD-1 checkpoint blockade: a case series
|
---|---|
Published in |
Journal for Immunotherapy of Cancer, May 2018
|
DOI | 10.1186/s40425-018-0352-8 |
Pubmed ID | |
Authors |
Melody J. Xu, Susan Wu, Adil I. Daud, Siegrid S. Yu, Sue S. Yom |
Abstract |
Patients with metastatic Merkel cell carcinoma (mMCC) who experience disease progression on immunotherapy have limited additional standard options. Given evidence of synergism between radiation therapy (RT) and immunotherapy, two patients progressing on PD-1 inhibition were referred for short-course RT. Two patients were found to have progressive mMCC on PD-1 inhibitor therapy and were treated with single-fraction palliative RT. Both patients were observed to have local control at irradiated regions, as well as durable abscopal response at unirradiated, out-of-field, sites of metastatic disease. Short-course RT is a compelling strategy that could be a means to augment response in patients with mMCC who show progression on immune checkpoint blockade. Ongoing clinical trials are investigating the relationship between RT and immunotherapy in mMCC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 67% |
Spain | 1 | 8% |
Singapore | 1 | 8% |
Unknown | 2 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 58% |
Scientists | 3 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 17% |
Professor | 4 | 13% |
Other | 3 | 10% |
Student > Bachelor | 2 | 7% |
Student > Master | 2 | 7% |
Other | 6 | 20% |
Unknown | 8 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 50% |
Nursing and Health Professions | 2 | 7% |
Unspecified | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Unknown | 11 | 37% |