Title |
Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
|
---|---|
Published in |
Biological Research, July 2015
|
DOI | 10.1186/s40659-015-0030-y |
Pubmed ID | |
Authors |
Guilan Cai, Shanshan Qiao, Kui Chen |
Abstract |
Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. In this study we revealed that a new microRNA (miR), the miR-221, was highly expressed in the glioma cells, and suppression of miR-221 resulted in decreased cellular proliferation, migration, and invasion in glioma cells. Mechanistic experiments validated that miR-221 participates in regulating glioma cells proliferation and invasion via suppression of a direct target gene, the Semaphorin 3B (SEMA3B). The rescue experiment with miR-221 and SEMA3B both knockdown results in significant reversion of miR-221 induced phenotypes. Taken together, our findings highlight an unappreciated role for miR-221 and SEMA3B in glioma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 41% |
Researcher | 5 | 23% |
Student > Bachelor | 3 | 14% |
Other | 1 | 5% |
Student > Doctoral Student | 1 | 5% |
Other | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 27% |
Medicine and Dentistry | 5 | 23% |
Agricultural and Biological Sciences | 4 | 18% |
Neuroscience | 2 | 9% |
Linguistics | 1 | 5% |
Other | 3 | 14% |
Unknown | 1 | 5% |