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Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B

Overview of attention for article published in Biological Research, July 2015
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3 X users

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Title
Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
Published in
Biological Research, July 2015
DOI 10.1186/s40659-015-0030-y
Pubmed ID
Authors

Guilan Cai, Shanshan Qiao, Kui Chen

Abstract

Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. In this study we revealed that a new microRNA (miR), the miR-221, was highly expressed in the glioma cells, and suppression of miR-221 resulted in decreased cellular proliferation, migration, and invasion in glioma cells. Mechanistic experiments validated that miR-221 participates in regulating glioma cells proliferation and invasion via suppression of a direct target gene, the Semaphorin 3B (SEMA3B). The rescue experiment with miR-221 and SEMA3B both knockdown results in significant reversion of miR-221 induced phenotypes. Taken together, our findings highlight an unappreciated role for miR-221 and SEMA3B in glioma.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 41%
Researcher 5 23%
Student > Bachelor 3 14%
Other 1 5%
Student > Doctoral Student 1 5%
Other 3 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 27%
Medicine and Dentistry 5 23%
Agricultural and Biological Sciences 4 18%
Neuroscience 2 9%
Linguistics 1 5%
Other 3 14%
Unknown 1 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2015.
All research outputs
#15,739,529
of 25,373,627 outputs
Outputs from Biological Research
#217
of 642 outputs
Outputs of similar age
#140,305
of 275,275 outputs
Outputs of similar age from Biological Research
#4
of 21 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 642 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,275 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.