Title |
Activating mutation in MET oncogene in familial colorectal cancer
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Published in |
BMC Cancer, October 2011
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DOI | 10.1186/1471-2407-11-424 |
Pubmed ID | |
Authors |
Deborah W Neklason, Michelle W Done, Nykole R Sargent, Ann G Schwartz, Hoda Anton-Culver, Constance A Griffin, Dennis J Ahnen, Joellen M Schildkraut, Gail E Tomlinson, Louise C Strong, Alexander R Miller, Jill E Stopfer, Randall W Burt |
Abstract |
In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherited colon cancer syndromes account for approximately 5%, leaving greater than 20% without clear genetic definition. Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Canada | 1 | 1% |
Unknown | 65 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 24% |
Student > Ph. D. Student | 11 | 16% |
Student > Master | 10 | 15% |
Other | 9 | 13% |
Student > Bachelor | 4 | 6% |
Other | 10 | 15% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 31% |
Biochemistry, Genetics and Molecular Biology | 17 | 25% |
Agricultural and Biological Sciences | 13 | 19% |
Social Sciences | 2 | 3% |
Psychology | 2 | 3% |
Other | 4 | 6% |
Unknown | 9 | 13% |