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Interaction between warfarin and short-term intravenous amiodarone in intensive care unit patients after cardiac surgery

Overview of attention for article published in Journal of Pharmaceutical Health Care and Sciences, May 2018
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Title
Interaction between warfarin and short-term intravenous amiodarone in intensive care unit patients after cardiac surgery
Published in
Journal of Pharmaceutical Health Care and Sciences, May 2018
DOI 10.1186/s40780-018-0110-6
Pubmed ID
Authors

Tomoki Takase, Hiroaki Ikesue, Makiko Tohi, Hiroshi Ueta, Hiroyuki Mima, Tadaaki Koyama, Tohru Hashida

Abstract

Amiodarone and warfarin are sometimes administered immediately after cardiac surgery. Although the interaction between long-term oral amiodarone and warfarin has been reported, the interaction between warfarin and short-term intravenous amiodarone has not been reported. In this study, we investigated the effect of short-term intravenous amiodarone on the anticoagulant effect of warfarin in patients who underwent cardiac surgery. We retrospectively reviewed the medical records of 11 patients who received oral warfarin before and after cardiac surgery, and loading doses of 125-150 mg or a 750 mg continuous infusion of amiodarone, or both in the intensive care unit (ICU) within 5 days after the surgery between July 2011 and January 2017. The prothrombin time-international normalized ratio (PT-INR)/daily warfarin dose (PT-INR/dose) was used as an indicator of anticoagulant effect. The values before surgery were considered as the baseline. The PT-INR and PT-INR/dose values were elevated in 7 and 10 patients, respectively, after amiodarone administration. The mean PT-INR values were not significantly different before and after amiodarone administration (2.13 ± 0.58 vs 2.29 ± 0.50, respectively, p = 0.643). In contrast, the mean PT-INR/dose values were significantly elevated after the administration of amiodarone (0.93 ± 0.46 vs 1.54 ± 0.63, respectively, p = 0.002). Short-term intravenous amiodarone enhanced the anticoagulant effect of warfarin in patients admitted to the ICU after cardiac surgery. We suggest that the dose of warfarin should be carefully adjusted for a few days after cardiac surgery if intravenous amiodarone is coadministered.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 9%
Student > Doctoral Student 1 9%
Student > Bachelor 1 9%
Student > Ph. D. Student 1 9%
Student > Master 1 9%
Other 2 18%
Unknown 4 36%
Readers by discipline Count As %
Medicine and Dentistry 5 45%
Pharmacology, Toxicology and Pharmaceutical Science 2 18%
Nursing and Health Professions 1 9%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2018.
All research outputs
#11,567,432
of 13,017,042 outputs
Outputs from Journal of Pharmaceutical Health Care and Sciences
#41
of 53 outputs
Outputs of similar age
#235,427
of 271,669 outputs
Outputs of similar age from Journal of Pharmaceutical Health Care and Sciences
#1
of 1 outputs
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So far Altmetric has tracked 53 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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