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Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline

Overview of attention for article published in BMC Biology, July 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)

Mentioned by

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5 tweeters

Citations

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46 Dimensions

Readers on

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69 Mendeley
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Title
Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline
Published in
BMC Biology, July 2015
DOI 10.1186/s12915-015-0159-8
Pubmed ID
Authors

Ho-Su Sin, Andrey V. Kartashov, Kazuteru Hasegawa, Artem Barski, Satoshi H. Namekawa

Abstract

The male germline transcriptome changes dramatically during the mitosis-to-meiosis transition to activate late spermatogenesis genes and to transiently suppress genes commonly expressed in somatic lineages and spermatogenesis progenitor cells, termed somatic/progenitor genes. These changes reflect epigenetic regulation. Induction of late spermatogenesis genes during spermatogenesis is facilitated by poised chromatin established in the stem cell phases of spermatogonia, whereas silencing of somatic/progenitor genes during meiosis and postmeiosis is associated with formation of bivalent domains which also allows the recovery of the somatic/progenitor program after fertilization. Importantly, during spermatogenesis mechanisms of epigenetic regulation on sex chromosomes are different from autosomes: X-linked somatic/progenitor genes are suppressed by meiotic sex chromosome inactivation without deposition of H3K27me3. Our results suggest that bivalent H3K27me3 and H3K4me2/3 domains are not limited to developmental promoters (which maintain bivalent domains that are silent throughout the reproductive cycle), but also underlie reversible silencing of somatic/progenitor genes during the mitosis-to-meiosis transition in late spermatogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Russia 1 1%
Unknown 66 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 25%
Researcher 15 22%
Student > Master 8 12%
Other 6 9%
Student > Bachelor 5 7%
Other 11 16%
Unknown 7 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 38%
Biochemistry, Genetics and Molecular Biology 25 36%
Medicine and Dentistry 2 3%
Computer Science 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 3 4%
Unknown 10 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2019.
All research outputs
#8,276,622
of 14,360,928 outputs
Outputs from BMC Biology
#1,009
of 1,242 outputs
Outputs of similar age
#105,788
of 235,589 outputs
Outputs of similar age from BMC Biology
#1
of 1 outputs
Altmetric has tracked 14,360,928 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,242 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.9. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them