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X Demographics
Mendeley readers
Attention Score in Context
| Title |
HIF-1α promotes the migration and invasion of hepatocellular carcinoma cells via the IL-8–NF-κB axis
|
|---|---|
| Published in |
Cellular & Molecular Biology Letters, May 2018
|
| DOI | 10.1186/s11658-018-0077-1 |
| Pubmed ID | |
| Authors |
Wenming Feng, Tao Xue, Sanxiong Huang, Qilin Shi, Chengwu Tang, Ge Cui, Guanghui Yang, Hui Gong, Huihui Guo |
| Abstract |
Hypoxia plays a critical role in many cancers. Hypoxia inducible factor-1α (HIF-1α) is an important mediator of the hypoxia response. It regulates the expression of various chemokines involved in tumor growth, angiogenesis and metastasis but the associated pathway needs further investigation. The expression level of HIF-1α was determined in hepatocellular carcinoma (HCC) cells. The correlation of interleukin-8 (IL-8) and HIF-1α was assessed by knocking down HIF-1α. These cells were also used to assess its influence on HCC cell migration and invasion was checked. Pyrrolidinedithiocarbamate (PDTC), an inhibitor of NF-κB, was used to confirm the associated signaling pathway. HIF-1α was significantly expressed in HCC cells and found to promote HCC cell migration and invasion in an IL-8-dependent manner. NF-κB was confirmed to be involved in the process. HIF-1α promotes HCC cell migration and invasion by modulating IL-8 via the NF-κB pathway. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 21% |
| Student > Ph. D. Student | 5 | 18% |
| Student > Master | 4 | 14% |
| Researcher | 2 | 7% |
| Student > Doctoral Student | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 9 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 18% |
| Biochemistry, Genetics and Molecular Biology | 5 | 18% |
| Agricultural and Biological Sciences | 2 | 7% |
| Arts and Humanities | 1 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 6 | 21% |
| Unknown | 8 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2018.
All research outputs
#18,633,675
of 23,083,773 outputs
Outputs from Cellular & Molecular Biology Letters
#252
of 487 outputs
Outputs of similar age
#255,910
of 331,171 outputs
Outputs of similar age from Cellular & Molecular Biology Letters
#8
of 19 outputs
Altmetric has tracked 23,083,773 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 487 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,171 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.