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Effects of ebselen and N-acetyl cysteine on replicative aging of primary human fibroblast strains

Overview of attention for article published in Immunity & Ageing, July 2015
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Title
Effects of ebselen and N-acetyl cysteine on replicative aging of primary human fibroblast strains
Published in
Immunity & Ageing, July 2015
DOI 10.1186/s12979-015-0035-y
Pubmed ID
Authors

Shiva Marthandan

Abstract

Administration of selected concentrations of ebselen and N-acetyl cysteine have been proven to display an antioxidant potential based on their effect on markers of T cell integrity and function in human peripheral blood mononuclear cells and CD4(+) T cell clones. Here we assessed the impact of various antioxidant concentrations on replicative aging of primary human fibroblast strains derived from embryonic lung (MRC-5) and foreskin (HFF). None of the antioxidant concentrations affected the cumulative population doublings, levels of oxidative DNA damage, intracellular GSH:GSSG ratio, potency of heat shock responses and the induction of senescence in both fibroblast strains. Our results showed no effect of both antioxidants on primary fibroblast strains and reveal their cell type specific antioxidant potential.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 50%
Student > Ph. D. Student 1 25%
Unknown 1 25%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 25%
Biochemistry, Genetics and Molecular Biology 1 25%
Agricultural and Biological Sciences 1 25%
Unknown 1 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2015.
All research outputs
#9,958,808
of 12,440,542 outputs
Outputs from Immunity & Ageing
#136
of 185 outputs
Outputs of similar age
#162,580
of 235,896 outputs
Outputs of similar age from Immunity & Ageing
#2
of 2 outputs
Altmetric has tracked 12,440,542 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 185 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,896 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.