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Whole genome sequence revealed the fine transmission map of carbapenem-resistant Klebsiella pneumonia isolates within a nosocomial outbreak

Overview of attention for article published in Antimicrobial Resistance and Infection Control, June 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

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17 tweeters

Citations

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11 Dimensions

Readers on

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54 Mendeley
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Title
Whole genome sequence revealed the fine transmission map of carbapenem-resistant Klebsiella pneumonia isolates within a nosocomial outbreak
Published in
Antimicrobial Resistance and Infection Control, June 2018
DOI 10.1186/s13756-018-0363-8
Pubmed ID
Authors

Wenjun Sui, Haijian Zhou, Pengcheng Du, Lijun Wang, Tian Qin, Mei Wang, Hongyu Ren, Yanfei Huang, Jing Hou, Chen, Xinxin Lu

Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major cause of nosocomial infections worldwide. The transmission route of CRKP isolates within an outbreak is rarely described. This study aimed to reveal the molecular characteristics and transmission route of CRKP isolates within an outbreak of nosocomial infection. Collecting case information, active screening and targeted environmental monitoring were carried out. The antibiotic susceptibility, drug-resistant genes, molecular subtype and whole genome sequence of CRKP strains were analyzed. Between October and December 2011, 26 CRKP isolates were collected from eight patients in a surgical intensive care unit and subsequent transfer wards of Beijing Tongren hospital, China. All 26 isolates harbored blaKPC-2, blaSHV-1, and blaCTX-M-15 genes, had the same or similar pulsed-field gel electrophoresis patterns, and belonged to the sequence type 11 (ST11) clone. By comprehensive consideration of genomic and epidemiological information, a putative transmission map was constructed, including identifying one case as an independent event distinct from the other seven cases, and revealing two transmissions starting from the same case. This study provided the first report confirming an outbreak caused by K. pneumoniae ST11 clone co-harboring the blaKPC-2, blaCTX-M-15, and blaSHV-1 genes, and suggested that comprehensive consideration of genomic and epidemiological data can yield a fine transmission map of an outbreak and facilitate the control of nosocomial transmission.

Twitter Demographics

The data shown below were collected from the profiles of 17 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Bachelor 7 13%
Student > Master 7 13%
Other 3 6%
Student > Postgraduate 3 6%
Other 10 19%
Unknown 14 26%
Readers by discipline Count As %
Medicine and Dentistry 10 19%
Biochemistry, Genetics and Molecular Biology 10 19%
Agricultural and Biological Sciences 5 9%
Immunology and Microbiology 4 7%
Psychology 2 4%
Other 7 13%
Unknown 16 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2019.
All research outputs
#2,041,662
of 15,881,336 outputs
Outputs from Antimicrobial Resistance and Infection Control
#352
of 900 outputs
Outputs of similar age
#55,748
of 281,995 outputs
Outputs of similar age from Antimicrobial Resistance and Infection Control
#1
of 2 outputs
Altmetric has tracked 15,881,336 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 900 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,995 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them