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Mendeley readers
Attention Score in Context
| Title |
Feasibility and safety of intrathecal transplantation of autologous bone marrow mesenchymal stem cells in horses
|
|---|---|
| Published in |
BMC Veterinary Research, March 2015
|
| DOI | 10.1186/s12917-015-0361-5 |
| Pubmed ID | |
| Authors |
Leandro Maia, Fernanda da Cruz Landim- Alvarenga, Marilda Onghero Taffarel, Carolina Nogueira de Moraes, Gisele Fabrino Machado, Guilherme Dias Melo, Rogério Martins Amorim |
| Abstract |
Recent studies have demonstrated numerous biological properties of mesenchymal stem cells and their potential application in treating complex diseases or injuries to tissues that have difficulty regenerating, such as those affecting the central and peripheral nervous system. Thus, therapies that use mesenchymal stem cells are promising because of their high capacity for self-regeneration, their low immunogenicity, and their paracrine, anti-inflammatory, immunomodulatory, anti-apoptotic and neuroprotective effects. In this context, the purpose of this study was to evaluate the feasibility and safety of intrathecal transplantation of bone marrow-derived mesenchymal stem cells in horses, for future application in the treatment of neurological diseases. During the neurological evaluations, no clinical signs were observed that were related to brain and/or spinal cord injury of the animals from the control group or the treated group. The hematological and cerebrospinal fluid results from day 1 and day 6 showed no significant differences (P > 0.05) between the treated group and the control group. Additionally, analysis of the expression of matrix metalloproteinase (MMP) -2 and -9 in the cerebrospinal fluid revealed only the presence of pro-MMP-2 (latent), with no significant difference (P > 0.05) between the studied groups. The results of the present study support the hypothesis of the feasibility and safety of intrathecal transplantation of autologous bone marrow-derived mesenchymal stem cells, indicating that it is a promising pathway for cell delivery for the treatment of neurological disorders in horses. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 4% |
| United States | 1 | 2% |
| New Zealand | 1 | 2% |
| Unknown | 46 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 14% |
| Student > Doctoral Student | 6 | 12% |
| Student > Bachelor | 6 | 12% |
| Other | 5 | 10% |
| Student > Ph. D. Student | 5 | 10% |
| Other | 15 | 30% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 22% |
| Veterinary Science and Veterinary Medicine | 8 | 16% |
| Agricultural and Biological Sciences | 8 | 16% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Neuroscience | 3 | 6% |
| Other | 9 | 18% |
| Unknown | 8 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2015.
All research outputs
#20,283,046
of 22,817,213 outputs
Outputs from BMC Veterinary Research
#2,417
of 3,050 outputs
Outputs of similar age
#221,113
of 261,491 outputs
Outputs of similar age from BMC Veterinary Research
#38
of 45 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,050 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,491 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.