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Integrins and their ligands in rheumatoid arthritis

Overview of attention for article published in Arthritis Research & Therapy, January 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

twitter
11 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
59 Dimensions

Readers on

mendeley
66 Mendeley
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Title
Integrins and their ligands in rheumatoid arthritis
Published in
Arthritis Research & Therapy, January 2011
DOI 10.1186/ar3464
Pubmed ID
Authors

Torsten Lowin, Rainer H Straub

Abstract

Integrins play an important role in cell adhesion to the extracellular matrix and other cells. Upon ligand binding, signaling is initiated and several intracellular pathways are activated. This leads to a wide variety of effects, depending on cell type. Integrin activation has been linked to proliferation, secretion of matrix-degrading enzymes, cytokine production, migration, and invasion. Dysregulated integrin expression is often found in malignant disease. Tumors use integrins to evade apoptosis or metastasize, indicating that integrin signaling has to be tightly controlled. During the course of rheumatoid arthritis, the synovial tissue is infiltrated by immune cells that secrete large amounts of cytokines. This pro-inflammatory milieu leads to an upregulation of integrin receptors and their ligands in the synovial tissue. As a consequence, integrin signaling is enhanced, leading to enhanced production of matrix-degrading enzymes and cytokines. Furthermore, in analogy to invading tumors, synovial fibroblasts start invading and degrading cartilage, thereby generating extracellular matrix debris that can further activate integrins.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 29%
Researcher 16 24%
Student > Master 9 14%
Student > Doctoral Student 5 8%
Other 4 6%
Other 8 12%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 27%
Medicine and Dentistry 15 23%
Biochemistry, Genetics and Molecular Biology 9 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Chemistry 4 6%
Other 10 15%
Unknown 6 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2020.
All research outputs
#1,991,390
of 17,067,437 outputs
Outputs from Arthritis Research & Therapy
#458
of 2,552 outputs
Outputs of similar age
#13,068
of 119,567 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 3 outputs
Altmetric has tracked 17,067,437 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,552 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,567 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them