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Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus

Overview of attention for article published in BMC Neuroscience, July 2015
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Title
Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus
Published in
BMC Neuroscience, July 2015
DOI 10.1186/s12868-015-0184-0
Pubmed ID
Authors

Milan Brázdil, Jan Cimbálník, Robert Roman, Daniel J Shaw, Matt M Stead, Pavel Daniel, Pavel Jurák, Josef Halámek

Abstract

Until now there has been no way of distinguishing between physiological and epileptic hippocampal ripples in intracranial recordings. In the present study we addressed this by investigating the effect of cognitive stimulation on interictal high frequency oscillations in the ripple range (80-250 Hz) within epileptic (EH) and non-epileptic hippocampus (NH). We analyzed depth EEG recordings in 10 patients with intractable epilepsy, in whom hippocampal activity was recorded initially during quiet wakefulness and subsequently during a simple cognitive task. Using automated detection of ripples based on amplitude of the power envelope, we analyzed ripple rate (RR) in the cognitive and resting period, within EH and NH. Compared to quiet wakefulness we observed a significant reduction of RR during cognitive stimulation in EH, while it remained statistically marginal in NH. Further, we investigated the direct impact of cognitive stimuli on ripples (i.e. immediately post-stimulus), which showed a transient statistically significant suppression of ripples in the first second after stimuli onset in NH only. Our results point to a differential reactivity of ripples within EH and NH to cognitive stimulation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 1%
France 1 1%
Unknown 65 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 21%
Student > Ph. D. Student 11 16%
Student > Master 11 16%
Student > Postgraduate 5 7%
Other 4 6%
Other 10 15%
Unknown 12 18%
Readers by discipline Count As %
Neuroscience 20 30%
Medicine and Dentistry 15 22%
Biochemistry, Genetics and Molecular Biology 3 4%
Psychology 3 4%
Computer Science 2 3%
Other 9 13%
Unknown 15 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2015.
All research outputs
#20,283,046
of 22,817,213 outputs
Outputs from BMC Neuroscience
#1,054
of 1,244 outputs
Outputs of similar age
#219,914
of 263,272 outputs
Outputs of similar age from BMC Neuroscience
#19
of 23 outputs
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So far Altmetric has tracked 1,244 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.