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Persistent hyperglycemia modulates gut immune function and microbiota in rats

Overview of attention for article published in Journal of Intensive Care, July 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)

Mentioned by

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7 tweeters
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2 Facebook pages

Citations

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3 Dimensions

Readers on

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25 Mendeley
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Title
Persistent hyperglycemia modulates gut immune function and microbiota in rats
Published in
Journal of Intensive Care, July 2015
DOI 10.1186/s40560-015-0101-8
Pubmed ID
Authors

Katsuya Mori, Takeshi Suzuki, Toru Igarashi, Kei Inoue, Takashi Asahara, Koji Nomoto, Hiroyuki Seki, Takashige Yamada, Shizuka Minamishima, Shizuko Kosugi, Nobuyuki Katori, Hiroshi Morisaki

Abstract

Since hyperglycemia-induced cellular dysfunction could be associated with alterations of the immune system, we tested the hypothesis that hyperglycemia augments the aberrant immune responses such as inflammation and differentiation of CD4(+) T lymphocytes in the mesenteric lymph nodes (MLNs), and induces alterations of microbiota both under physiological and pathological conditions. Male Wistar rats were randomly allocated into 4 groups: Control and Endotoxemia (lipopolysaccharide, LPS 1 mg/kg) with or without hyperglycemia. The hyperglycemia groups were administered glucose solution (10-40 %), while the normoglycemia groups were administered saline. Alterations of the mRNA expressions of inflammatory cytokines and CD4(+) T lymphocyte transcriptional factor expressions in the MLNs, and those of the intestinal microbiota were analyzed at 24 hr. Hyperglycemia was kept approximately 250-350 mg/dL during the 24 hr study period. At the end of 24 hr, hyperglycemia augmented the mRNA expressions of interleukin (IL)-1β and IL-6 in the MLNs, while both the helper T (Th) 2 and regulatory-T (Treg) transcriptional factors were simultaneously up-regulated under non-endotoxemic condition. LPS injection significantly modulated the obligate anaerobe bacterial populations of the Bacteroidetes class, and altered the population sizes of the Clostridium perfringens and the Bacteroides fragilis subgroup. Hyperglycemia did not enhance these alterations of the microbiota evoked by LPS, although it did modify the bacterial populations of the L. reuteri subgroup and staphylococci in healthy condition without endotoxemia. The present study indicates that both gut immune function and microbiota are significantly modulated by persistent hyperglycemia.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 48%
Student > Master 3 12%
Other 2 8%
Student > Ph. D. Student 2 8%
Student > Bachelor 1 4%
Other 2 8%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 28%
Medicine and Dentistry 7 28%
Biochemistry, Genetics and Molecular Biology 3 12%
Immunology and Microbiology 3 12%
Veterinary Science and Veterinary Medicine 1 4%
Other 0 0%
Unknown 4 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2017.
All research outputs
#9,388,135
of 17,414,782 outputs
Outputs from Journal of Intensive Care
#231
of 417 outputs
Outputs of similar age
#95,727
of 240,690 outputs
Outputs of similar age from Journal of Intensive Care
#1
of 1 outputs
Altmetric has tracked 17,414,782 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 417 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,690 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them