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Neoinnervation and neovascularization of acellular pericardial-derived scaffolds in myocardial infarcts

Overview of attention for article published in Stem Cell Research & Therapy, May 2015
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Title
Neoinnervation and neovascularization of acellular pericardial-derived scaffolds in myocardial infarcts
Published in
Stem Cell Research & Therapy, May 2015
DOI 10.1186/s13287-015-0101-6
Pubmed ID
Authors

Carolina Gálvez-Montón, M. Teresa Fernandez-Figueras, Mercè Martí, Carolina Soler-Botija, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Aida Llucià-Valldeperas, Ángel Raya, Antoni Bayes-Genis

Abstract

Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovascularization in an acellular pericardial-derived scaffold used as a myocardial bioimplant. To this end, seventeen swine were submitted to a myocardial infarction followed by implantation of a decellularized human pericardial-derived scaffold. After 30 days, animals were sacrificed and hearts were analyzed with hematoxylin/eosin, and Masson's and Gallego's modified trichrome staining. Immunohistochemistry was carried out to detect nerve fibers within the cardiac bioimplant using βIII tubulin and S100 labeling. Isolectin B4, smooth muscle actin, CD31, Von Willebrand factor, cardiac troponin I, and elastin antibodies were used to study scaffold vascularization. Transmission electron microscopy was performed to confirm the presence of vascular and nervous ultrastructures. Left ventricular ejection fraction (LVEF), cardiac output (CO), stroke volume (SV), end diastolic volume (EDV), end systolic volume (ESV), end diastolic wall mass (EDWM), and infarct size were assessed using magnetic resonance imaging (MRI). Newly formed nerve fibers composed of several amyelinated axons as the afferent nerve endings of the heart were identified by immunohistochemistry. Additionally, neovessel formation occurred spontaneously as small and large Isolectin B4-positive blood vessels within the scaffold. In summary, this study demonstrates for the first time the neoformation of vessels and nerves in cell-free cardiac scaffolds applied over infarcted tissue. Moreover, MRI analysis showed a significant improvement in LVEF (P=0.03), CO (P=0.01), and a 43% decrease in infarct size (P=0.007).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Portugal 1 2%
Unknown 52 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 24%
Researcher 11 20%
Student > Postgraduate 4 7%
Student > Master 4 7%
Student > Bachelor 3 6%
Other 7 13%
Unknown 12 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 17%
Agricultural and Biological Sciences 9 17%
Medicine and Dentistry 6 11%
Materials Science 5 9%
Engineering 3 6%
Other 5 9%
Unknown 17 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2016.
All research outputs
#15,340,815
of 22,818,766 outputs
Outputs from Stem Cell Research & Therapy
#1,342
of 2,418 outputs
Outputs of similar age
#156,570
of 266,638 outputs
Outputs of similar age from Stem Cell Research & Therapy
#33
of 53 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,638 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.