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Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case–control study

Overview of attention for article published in Lipids in Health and Disease, July 2015
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Title
Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case–control study
Published in
Lipids in Health and Disease, July 2015
DOI 10.1186/s12944-015-0078-2
Pubmed ID
Authors

Qian Yang, Rui-Xing Yin, Yi-Jiang Zhou, Xiao-Li Cao, Tao Guo, Wu-Xian Chen

Abstract

The v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B gene (MAFB) has been associated with serum lipid levels in the Eurpean population, but little is known about such association in the Chinese population or in atherosclerosis-related patients. Therefore, the purpose of the present study was to assess the association of the single nucleotide polymorphisms (SNPs) in the MAFB and serum lipid levels and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Chinese population. A total of 1,065 unrelated patients (CAD, 525 and IS, 540) and 539 healthy controls were recruited in this study. Genotypes of the MAFB rs2902940 and rs6102059 SNPs were determined by the Snapshot technology platform. The rs2902940AA genotype was associated with an increased risk of CAD (adjusted OR = 1.63, 95 % CI = 1.07-2.48, P = 0.023) and IS (adjusted OR = 1.69, 95 % CI = 1.09-2.61, P = 0.017). The rs2902940GA/AA genotypes were also associated with an increased risk of CAD (adjusted OR = 1.56, 95 % CI = 1.04-2.32, P = 0.030 for GA/AA vs. GG) and IS (adjusted OR = 1.72, 95 % CI = 1.14-2.60, P = 0.010 for GA/AA vs. GG). Significant interactions were observed only in those with higher body mass index (BMI), hypertension and diabetes (P < 0.05). The subjects with rs2902940GA/AA genotypes in controls had lower serum ApoAI levels than the subjects with GG genotype (P = 0.024). The rs2902940A allele carriers in the MAFB conferred a decreased serum ApoAI level in controls and an increased risk of CAD and IS. The rs2902940GA/AA genotypes interacted with higher BMI, hypertension and diabetes to contribute the risk of CAD and IS.

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The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 13%
Other 3 13%
Researcher 3 13%
Professor > Associate Professor 3 13%
Student > Postgraduate 2 9%
Other 5 22%
Unknown 4 17%
Readers by discipline Count As %
Medicine and Dentistry 7 30%
Agricultural and Biological Sciences 5 22%
Biochemistry, Genetics and Molecular Biology 4 17%
Computer Science 1 4%
Immunology and Microbiology 1 4%
Other 1 4%
Unknown 4 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2015.
All research outputs
#17,765,819
of 22,818,766 outputs
Outputs from Lipids in Health and Disease
#924
of 1,450 outputs
Outputs of similar age
#176,726
of 263,272 outputs
Outputs of similar age from Lipids in Health and Disease
#20
of 33 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,450 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,272 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.