Title |
Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis
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Published in |
Acta Neuropathologica Communications, July 2015
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DOI | 10.1186/s40478-015-0223-1 |
Pubmed ID | |
Authors |
Gijs Kooij, Rens Braster, Jasper J. Koning, Lisa C. Laan, Sandra J. van Vliet, Tamara Los, Anne Marieke Eveleens, Susanne M. A. van der Pol, Elisabeth Förster-Waldl, Kaan Boztug, Alexandre Belot, Katka Szilagyi, Timo K. van den Berg, Jaap D. van Buul, Marjolein van Egmond, Helga E. de Vries, Richard D. Cummings, Christine D. Dijkstra, Irma van Die |
Abstract |
The inverse correlation between prevalence of auto-immune disorders like the chronic neuro-inflammatory disease multiple sclerosis (MS) and the occurrence of helminth (worm) infections, suggests that the helminth-trained immune system is protective against auto-immunity. As monocytes are regarded as crucial players in the pathogenesis of auto-immune diseases, we explored the hypothesis that these innate effector cells are prime targets for helminths to exert their immunomodulatory effects. Here we show that soluble products of the porcine nematode Trichuris suis (TsSP) are potent in changing the phenotype and function of human monocytes by skewing classical monocytes into anti-inflammatory patrolling cells, which exhibit reduced trans-endothelial migration capacity in an in vitro model of the blood-brain barrier. Mechanistically, we identified the mannose receptor as the TsSP-interacting monocyte receptor and we revealed that specific downstream signalling occurs via protein kinase C (PKC), and in particular PKCδ. This study provides comprehensive mechanistic insight into helminth-induced immunomodulation, which can be therapeutically exploited to combat various auto-immune disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 43% |
United Kingdom | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 20% |
Researcher | 9 | 14% |
Student > Bachelor | 8 | 13% |
Other | 5 | 8% |
Student > Master | 4 | 6% |
Other | 12 | 19% |
Unknown | 13 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 11 | 17% |
Medicine and Dentistry | 9 | 14% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Agricultural and Biological Sciences | 7 | 11% |
Neuroscience | 4 | 6% |
Other | 10 | 16% |
Unknown | 15 | 23% |