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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Phylodynamic analysis of the canine distemper virus hemagglutinin gene
|
|---|---|
| Published in |
BMC Veterinary Research, July 2015
|
| DOI | 10.1186/s12917-015-0491-9 |
| Pubmed ID | |
| Authors |
Guan-Ming Ke, Chin-Hsiang Ho, Meng-Jung Chiang, Bintou Sanno-Duanda, Cheng-Shu Chung, Maw-Yeong Lin, Yong-Ying Shi, Ming-Hui Yang, Yu-Chang Tyan, Pao-Chi Liao, Pei-Yu Chu |
| Abstract |
Canine distemper (CD) is one of the most contagious and lethal viral diseases in dogs. Despite the widespread use of vaccines, the prevalence of the CD virus (CDV) has increased at an alarming rate in recent years. In this phylodynamic study, we investigated the spatiotemporal modes of dispersal, viral demographic trends, and effectiveness of vaccines for CDV. A total of 188 full-length CDV hemagglutinin (H) gene sequences dataset were subjected to recombination analysis, including seven from modified live vaccine (MLV) strains and 12 from Taiwan specimens. After excluding the MLV strains and potential recombinant strains, alignments of 176 of 188 previous CDV strains were further used to analyze phylodynamic characteristics, and evidence of selection, and co-evolution. The CDV genotype consisted of MLV-associated genotypes such as America-1 and Rockborn-like strains, which were characterized by long terminal branches and no distinct geographical patterns among lineages. In contrast, wild-type isolates clustered into lineages with a spatiotemporal structure and short terminal branches. Co-circulation and extensive diversification were simultaneously observed. The sequence variation signature was shaped by both geographic diversity and host tropism. Codon 506 was identified as a multi-epistatic interacting in the H protein. The topological signature revealed in this study suggests different epidemic scenarios. For example, a ladder-like backbone is a hallmark of directional selection, and cladogenesis at long terminal branches indicates the emergence of a surviving lineage. The stable effective viral population of CDV indicate the effectiveness of vaccines currently used to control the virus. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 81 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 18% |
| Student > Master | 13 | 16% |
| Student > Bachelor | 13 | 16% |
| Student > Ph. D. Student | 10 | 12% |
| Professor > Associate Professor | 5 | 6% |
| Other | 12 | 15% |
| Unknown | 14 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 20 | 24% |
| Agricultural and Biological Sciences | 17 | 21% |
| Biochemistry, Genetics and Molecular Biology | 9 | 11% |
| Immunology and Microbiology | 7 | 9% |
| Medicine and Dentistry | 6 | 7% |
| Other | 6 | 7% |
| Unknown | 17 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2015.
All research outputs
#17,766,929
of 22,818,766 outputs
Outputs from BMC Veterinary Research
#1,680
of 3,050 outputs
Outputs of similar age
#176,726
of 263,272 outputs
Outputs of similar age from BMC Veterinary Research
#40
of 73 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,050 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,272 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.