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High-grade B-cell lymphoma with MYC and BCL2 rearrangements arising in a composite lymphoma

Overview of attention for article published in Diagnostic Pathology, May 2018
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Title
High-grade B-cell lymphoma with MYC and BCL2 rearrangements arising in a composite lymphoma
Published in
Diagnostic Pathology, May 2018
DOI 10.1186/s13000-018-0714-z
Pubmed ID
Authors

Alison M. Moore, Olga Moshkin, Gordon J. Swain, Susan Crocker, David P. LeBrun

Abstract

We report the first case of composite lymphoma consisting of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), follicular lymphoma (FL) and high-grade B-cell lymphoma with MYC and BCL2 rearrangements within the same needle biopsy in which a clonal relationship between the FL and high-grade B-cell lymphoma components was demonstrated by molecular cytogenetics. An 85-year-old man presented with masses in his neck and right groin. Cutting needle biopsy of the inguinal mass revealed the three lymphoma types which were morphologically, immunophenotypically and topographically distinct. Fluorescence in situ hybridization (FISH) identified an IGH-BCL2 rearrangement in both the FL and high-grade B-cell components while a MYC rearrangement was detected in the high-grade B-cell component alone. Our findings suggest that the high-grade lymphoma with MYC and BCL2 translocations evolved through transformation of the FL by a process that entailed acquisition of the MYC translocation. No clonal relationship between the FL and CLL/SLL components was evident since the IGH-BCL2 rearrangement was present in in the former but not the latter. This unique case of co-localized FL, CLL/SLL, and high-grade B-cell lymphoma contributes to our understanding of the clonal relationships that may exist between the components of composite lymphomas.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 25%
Student > Master 3 19%
Researcher 2 13%
Student > Ph. D. Student 2 13%
Student > Bachelor 1 6%
Other 2 13%
Unknown 2 13%
Readers by discipline Count As %
Medicine and Dentistry 10 63%
Economics, Econometrics and Finance 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Unknown 4 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2018.
All research outputs
#10,399,108
of 13,040,510 outputs
Outputs from Diagnostic Pathology
#507
of 805 outputs
Outputs of similar age
#203,261
of 271,353 outputs
Outputs of similar age from Diagnostic Pathology
#1
of 3 outputs
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