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Association of virulence gene expression with colistin-resistance in Acinetobacter baumannii: analysis of genotype, antimicrobial susceptibility, and biofilm formation

Overview of attention for article published in Annals of Clinical Microbiology and Antimicrobials, June 2018
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  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

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7 tweeters

Citations

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11 Dimensions

Readers on

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42 Mendeley
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Title
Association of virulence gene expression with colistin-resistance in Acinetobacter baumannii: analysis of genotype, antimicrobial susceptibility, and biofilm formation
Published in
Annals of Clinical Microbiology and Antimicrobials, June 2018
DOI 10.1186/s12941-018-0277-6
Pubmed ID
Authors

Abbas Bahador, Zahra Farshadzadeh, Reza Raoofian, Masoumeh Mokhtaran, Babak Pourakbari, Maryam Pourhajibagher, Farhad B. Hashemi

Abstract

Acinetobacter baumannii causes difficult-to-treat nosocomial infections, which often lead to morbidity due to the development of antimicrobial drug resistance and expression of virulence genes. Data regarding the association of resistance to colistin, a last treatment option, and the virulence gene expression of A. baumannii is scarce. We evaluated the MLVA genotype, antimicrobial resistance, and biofilm formation of 100 A. baumannii isolates from burn patients, and further compared the in vitro and in vivo expression of four virulence genes among five colistin-resistant A. baumannii (Cst-R-AB) isolates. Five Cst-R-AB isolates were tested; one from the present study, and four isolated previously. Our results showed that reduced expression of recA, along with increased in vivo expression of lpsB, dnaK, and blsA; are associated with colistin resistance among Cst-R-AB isolates. Differences in virulence gene expressions among Cst-R-AB isolates, may in part explain common discrepant in vitro vs. in vivo susceptibility data during treatment of infections caused by Cst-R-AB. Our findings highlight the intricate relationship between colistin-resistance and virulence among A. baumannii isolates, and underscore the importance of examining the interactions between virulence and antimicrobial resistance toward efforts to control the spread of multidrug-resistant A. baumannii (MDR-AB) isolates, and also to reduce disease severity in burn patients with MDR-AB infection.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 17%
Student > Bachelor 5 12%
Student > Postgraduate 4 10%
Professor > Associate Professor 4 10%
Student > Master 3 7%
Other 6 14%
Unknown 13 31%
Readers by discipline Count As %
Medicine and Dentistry 8 19%
Biochemistry, Genetics and Molecular Biology 8 19%
Immunology and Microbiology 5 12%
Nursing and Health Professions 2 5%
Agricultural and Biological Sciences 2 5%
Other 2 5%
Unknown 15 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2018.
All research outputs
#10,262,432
of 18,914,672 outputs
Outputs from Annals of Clinical Microbiology and Antimicrobials
#150
of 525 outputs
Outputs of similar age
#127,431
of 292,469 outputs
Outputs of similar age from Annals of Clinical Microbiology and Antimicrobials
#1
of 1 outputs
Altmetric has tracked 18,914,672 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 525 research outputs from this source. They receive a mean Attention Score of 4.5. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,469 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them