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Repetitive transcranial magnetic stimulation (rTMS) in alcohol dependence: study protocol of a randomized controlled clinical trial of efficacy and working mechanisms

Overview of attention for article published in BMC Psychiatry, June 2018
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Title
Repetitive transcranial magnetic stimulation (rTMS) in alcohol dependence: study protocol of a randomized controlled clinical trial of efficacy and working mechanisms
Published in
BMC Psychiatry, June 2018
DOI 10.1186/s12888-018-1759-y
Pubmed ID
Authors

Renée S. Schluter, Ruth J. van Holst, Anna E. Goudriaan

Abstract

High frequency repetitive transcranial magnetic stimulation (HF-rTMS) has gained interest as a neuromodulation treatment technique for alcohol dependence. Single sessions of HF-rTMS have consistently shown to decrease craving for substances. However, the results of randomized controlled clinical trials investigating the effect of multiple HF-rTMS sessions in alcohol dependence on abstinence rates and craving are inconsistent. Furthermore, they lack information on the effect of HF-rTMS on cognition and brain functioning. A single center, single blind, randomized controlled trial with 80 abstinent alcohol dependent subjects in treatment randomized (1:1) to either treatment as usual (TAU) plus ten sessions of active HF-rTMS or TAU plus 10 sessions of placebo/ sham HF-rTMS will be performed. The effects of ten HF-rTMS sessions on craving and neurocognitive functions are obtained. In addition a subset of participants will undergo an MR scanning session before the first and after the last HF-rTMS session in order to investigate the effect of ten HF-rTMS sessions on brain functioning. The primary outcome is the continued abstinence rate after the add-on HF-rTMS treatment. This study uses a randomized controlled trial to examine the clinical, neurocognitive and brain functioning effects of ten add-on HF-rTMS sessions in alcohol dependent individuals in treatment. If the add-on treatment is effective, this may add to the evidence needed for approval of this additional treatment method for alcohol dependence by regulatory authorities. The Netherlands National Trial Register (NTR), NTR5291 , 6-July-2015.

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Geographical breakdown

Country Count As %
Unknown 100 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 25 25%
Student > Master 15 15%
Student > Ph. D. Student 9 9%
Researcher 6 6%
Professor 4 4%
Other 9 9%
Unknown 32 32%
Readers by discipline Count As %
Psychology 23 23%
Neuroscience 13 13%
Medicine and Dentistry 11 11%
Nursing and Health Professions 7 7%
Agricultural and Biological Sciences 2 2%
Other 7 7%
Unknown 37 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2019.
All research outputs
#17,978,863
of 23,088,369 outputs
Outputs from BMC Psychiatry
#3,756
of 4,768 outputs
Outputs of similar age
#238,495
of 329,877 outputs
Outputs of similar age from BMC Psychiatry
#116
of 126 outputs
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