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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination
|
|---|---|
| Published in |
Journal for Immunotherapy of Cancer, June 2018
|
| DOI | 10.1186/s40425-018-0361-7 |
| Pubmed ID | |
| Authors |
Jun Gong, Thang Q. Le, Erminia Massarelli, Andrew E. Hendifar, Richard Tuli |
| Abstract |
Several inhibitors of programmed cell death-1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved as a form of immunotherapy for multiple cancers. Ionizing radiation therapy (RT) has been shown to enhance the priming and effector phases of the antitumor T-cell response rendering it an attractive therapy to combine with PD-1/PD-L1 inhibitors. Preclinical data support the rational combination of the 2 modalities and has paved way for the clinical development of the combination across a spectrum of cancers. In this review, we highlight the preclinical and clinical development of combined RT and PD-1/PD-L1 blockade to date. In addition to a comprehensive evaluation of available safety and efficacy data, we discuss important points of consideration in clinical trial design for this promising combination. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 38% |
| Spain | 7 | 22% |
| Singapore | 2 | 6% |
| France | 1 | 3% |
| Unknown | 10 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 53% |
| Scientists | 9 | 28% |
| Practitioners (doctors, other healthcare professionals) | 4 | 13% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 143 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 16% |
| Student > Master | 14 | 10% |
| Other | 13 | 9% |
| Student > Bachelor | 12 | 8% |
| Student > Ph. D. Student | 9 | 6% |
| Other | 25 | 17% |
| Unknown | 47 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 29% |
| Biochemistry, Genetics and Molecular Biology | 20 | 14% |
| Immunology and Microbiology | 9 | 6% |
| Agricultural and Biological Sciences | 3 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 13 | 9% |
| Unknown | 53 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2024.
All research outputs
#1,114,021
of 25,401,381 outputs
Outputs from Journal for Immunotherapy of Cancer
#259
of 3,433 outputs
Outputs of similar age
#24,060
of 342,866 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#10
of 46 outputs
Altmetric has tracked 25,401,381 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,433 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,866 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.