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Cost-effectiveness analysis of dabigatran and anticoagulation monitoring strategies of vitamin K antagonist

Overview of attention for article published in BMC Health Services Research, July 2015
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  • Good Attention Score compared to outputs of the same age (68th percentile)

Mentioned by

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7 tweeters

Citations

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4 Dimensions

Readers on

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31 Mendeley
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Title
Cost-effectiveness analysis of dabigatran and anticoagulation monitoring strategies of vitamin K antagonist
Published in
BMC Health Services Research, July 2015
DOI 10.1186/s12913-015-0934-9
Pubmed ID
Authors

Misericòrdia Carles, Max Brosa, Juan Carlos Souto, Josep Maria Garcia-Alamino, Gordon Guyatt, Pablo Alonso-Coello

Abstract

Vitamin K antagonists are commonly used for the prevention of thromboembolic events. Patient self-monitoring of vitamin K antagonists has proved superior to usual care. Dabigatran has been shown, relative to warfarin, to reduce thromboembolic events without increasing bleeding. We constructed a Markov model to compare vitamin K self-monitoring strategies to dabigatran including effectiveness and costs of monitoring and complications (thromboembolism and major bleeding). The model was used to project the incidence of these complications, life years, quality-adjusted life years, and health system costs with anticoagulant treatment throughout life. The analysis was conducted from the health system perspective and from the societal perspective. Low quality evidence suggests that self-monitoring is at least as effective as dabigatran for the outcomes of thrombosis, bleeding and death. Moderate quality evidence that patient self-monitoring is more effective than other forms of monitoring degree of anticoagulation with vitamin K antagonists, reducing the relative risk of thromboembolism by 41 % and death by 34 %. The cost per quality adjusted year gained relative to other warfarin monitoring strategies is well below 30,000 € in the short term, and is a dominant alternative from the fourth year. In comparison with dabigatran, the lower annual cost and its equivalence in terms of effectiveness made self-monitoring the dominant option. These results were confirmed in the probabilistic sensitivity analysis. We have moderate quality evidence that self-monitoring of vitamin K antagonists is a cost-effective alternative compared with hospital and primary care monitoring, and low quality evidence, compared with dabigatran. Our analyses contrast with the available cost analysis of dabigatran and usual care of anticoagulated patients.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 2 6%
Student > Bachelor 2 6%
Lecturer 1 3%
Student > Ph. D. Student 1 3%
Student > Master 1 3%
Other 0 0%
Unknown 24 77%
Readers by discipline Count As %
Medicine and Dentistry 4 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Chemistry 1 3%
Engineering 1 3%
Unknown 24 77%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2016.
All research outputs
#6,360,638
of 21,033,636 outputs
Outputs from BMC Health Services Research
#3,170
of 7,002 outputs
Outputs of similar age
#75,610
of 248,077 outputs
Outputs of similar age from BMC Health Services Research
#1
of 1 outputs
Altmetric has tracked 21,033,636 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,002 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,077 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them