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X Demographics
Mendeley readers
Attention Score in Context
| Title |
MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis
|
|---|---|
| Published in |
Genome Biology, June 2018
|
| DOI | 10.1186/s13059-018-1442-0 |
| Pubmed ID | |
| Authors |
Yin Tong, Jianlong Sun, Chi Fat Wong, Qingzheng Kang, Beibei Ru, Ching Ngar Wong, April Sheila Chan, Suet Yi Leung, Jiangwen Zhang |
| Abstract |
Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epigenetic editing to support the accuracy and efficiency of our tool. Oncogenic and lineage-specific transcription factors are shown to aberrantly shape the methylation landscape by modifying tumor-subtype core regulatory circuitry. Notably, the gene regulatory networks orchestrated by enhancer methylation across different cancer types are seen to converge on a common architecture. MICMIC is available on https://github.com/ZhangJlab/MICMIC . |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 25% |
| United Kingdom | 7 | 25% |
| Australia | 1 | 4% |
| Spain | 1 | 4% |
| China | 1 | 4% |
| Norway | 1 | 4% |
| Guinea | 1 | 4% |
| Unknown | 9 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 16 | 57% |
| Members of the public | 8 | 29% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 28% |
| Researcher | 8 | 17% |
| Student > Bachelor | 6 | 13% |
| Student > Master | 6 | 13% |
| Student > Doctoral Student | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 7 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 41% |
| Agricultural and Biological Sciences | 10 | 22% |
| Engineering | 4 | 9% |
| Environmental Science | 1 | 2% |
| Computer Science | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 8 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2018.
All research outputs
#2,563,495
of 25,382,440 outputs
Outputs from Genome Biology
#2,053
of 4,468 outputs
Outputs of similar age
#51,672
of 343,126 outputs
Outputs of similar age from Genome Biology
#28
of 40 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,468 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,126 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.