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Extracellular cyclophilin A possesses chemotaxic activity in cattle

Overview of attention for article published in Veterinary Research, July 2015
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1 tweeter

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Title
Extracellular cyclophilin A possesses chemotaxic activity in cattle
Published in
Veterinary Research, July 2015
DOI 10.1186/s13567-015-0212-1
Pubmed ID
Authors

Satoru Takanashi, Tomonori Nochi, Miku Abe, Nanami Itaya, Megumi Urakawa, Katsuyoshi Sato, Tao Zhuang, Saori Umemura, Tomohito Hayashi, Yoshio Kiku, Haruki Kitazawa, Michael T. Rose, Kouichi Watanabe, Hisashi Aso

Abstract

Cyclophilin A (CyPA) was originally discovered in bovine thymocytes as a cytosolic binding protein of the immunosuppressive drug cyclosporine A. Recent studies have revealed that in mice and humans, CyPA is secreted from cells in injured or infected tissues and plays a role in recruiting inflammatory cells in those tissues. Here we found that in cattle abundant level of extracellular CyPA was observed in tissues with inflammation. To aid in investigating the role of extracellular CyPA in cattle, we generated recombinant bovine CyPA (rbCyPA) and tested its biological activity as an inflammatory mediator. When bovine peripheral blood cells were treated with rbCyPA in vitro, we observed that rbCyPA reacts with the membranous surface of granulocytes, monocytes and lymphocytes. Chemotaxis analysis showed that the granulocytes migrate toward rbCyPA and the migration is inhibited by pre-treatment with an anti-bovine CyPA antibody. These results indicate that, as for mice and humans, extracellular CyPA possesses chemotactic activity to recruit inflammatory cells (e.g., granulocytes) in cattle, and could thus be a potential therapeutic target for the treatment of inflammation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 33%
Student > Master 3 20%
Researcher 2 13%
Librarian 1 7%
Student > Doctoral Student 1 7%
Other 2 13%
Unknown 1 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 27%
Biochemistry, Genetics and Molecular Biology 3 20%
Chemistry 2 13%
Immunology and Microbiology 2 13%
Computer Science 1 7%
Other 1 7%
Unknown 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2015.
All research outputs
#10,214,248
of 12,787,140 outputs
Outputs from Veterinary Research
#607
of 804 outputs
Outputs of similar age
#160,146
of 233,876 outputs
Outputs of similar age from Veterinary Research
#6
of 6 outputs
Altmetric has tracked 12,787,140 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 804 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,876 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.