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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Obesity as risk factor for subtypes of breast cancer: results from a prospective cohort study
|
|---|---|
| Published in |
BMC Cancer, May 2018
|
| DOI | 10.1186/s12885-018-4548-6 |
| Pubmed ID | |
| Authors |
Cina J. Nattenmüller, Mark Kriegsmann, Disorn Sookthai, Renée Turzanski Fortner, Annika Steffen, Britta Walter, Theron Johnson, Jutta Kneisel, Verena Katzke, Manuela Bergmann, Hans Peter Sinn, Peter Schirmacher, Esther Herpel, Heiner Boeing, Rudolf Kaaks, Tilman Kühn |
| Abstract |
Earlier epidemiological studies indicate that associations between obesity and breast cancer risk may not only depend on menopausal status and use of exogenous hormones, but might also differ by tumor subtype. Here, we evaluated whether obesity is differentially associated with the risk of breast tumor subtypes, as defined by 6 immunohistochemical markers (ER, PR, HER2, Ki67, Bcl-2 and p53, separately and combined), in the prospective EPIC-Germany Study (n = 27,012). Formalin-fixed and paraffin-embedded (FFPE) tumor tissues of 657 incident breast cancer cases were used for histopathological analyses. Associations between BMI and breast cancer risk across subtypes were evaluated by multivariable Cox regression models stratified by menopausal status and hormone therapy (HT) use. Among postmenopausal non-users of HT, higher BMI was significantly associated with an increased risk of less aggressive, i.e. ER+, PR+, HER2-, Ki67low, Bcl-2+ and p53- tumors (HR per 5 kg/m2: 1.44 [1.10, 1.90], p = 0.009), but not with risk of more aggressive tumor subtypes. Among postmenopausal users of HT, BMI was significantly inversely associated with less aggressive tumors (HR per 5 kg/m2: 0.68 [0.50, 0.94], p = 0.018). Finally, among pre- and perimenopausal women, Cox regression models did not reveal significant linear associations between BMI and risk of any tumor subtype, although analyses by BMI tertiles showed a significantly lower risk of less aggressive tumors for women in the highest tertile (HR: 0.55 [0.33, 0.93]). Overall, our results suggest that obesity is related to risk of breast tumors with lower aggressiveness, a finding that requires replication in larger-scale analyses of pooled prospective data. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 25% |
| Romania | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 120 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 18% |
| Researcher | 15 | 13% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 9 | 8% |
| Student > Ph. D. Student | 5 | 4% |
| Other | 17 | 14% |
| Unknown | 41 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 23% |
| Biochemistry, Genetics and Molecular Biology | 19 | 16% |
| Nursing and Health Professions | 9 | 8% |
| Chemistry | 4 | 3% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 9 | 8% |
| Unknown | 47 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2018.
All research outputs
#14,131,870
of 23,088,369 outputs
Outputs from BMC Cancer
#3,245
of 8,379 outputs
Outputs of similar age
#180,773
of 331,177 outputs
Outputs of similar age from BMC Cancer
#74
of 177 outputs
Altmetric has tracked 23,088,369 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,379 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,177 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 177 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.