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Antiepileptic drugs in critically ill patients

Overview of attention for article published in Critical Care, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

twitter
163 tweeters
facebook
4 Facebook pages

Citations

dimensions_citation
37 Dimensions

Readers on

mendeley
228 Mendeley
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Title
Antiepileptic drugs in critically ill patients
Published in
Critical Care, June 2018
DOI 10.1186/s13054-018-2066-1
Pubmed ID
Authors

Salia Farrokh, Pouya Tahsili-Fahadan, Eva K. Ritzl, John J. Lewin, Marek A. Mirski

Abstract

The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, drug factors, such as onset of action and side effects, and patient factors, such as age, renal, and hepatic function, should be taken into account. It is important to note that the altered physiology of critically ill patients as well as pharmacological and nonpharmacological interventions such as renal replacement therapy, extracorporeal membrane oxygenation, and target temperature management may lead to therapeutic failure or toxicity. This may be even more challenging with the availability of newer antiepileptics where the evidence for their use in critically ill patients is limited. This article reviews the pharmacokinetics and pharmacodynamics of antiepileptics as well as application of these principles when dosing antiepileptics and monitoring serum levels in critically ill patients. The selection of the most appropriate anticonvulsant to treat seizure and status epileptics as well as the prophylactic use of these agents in this setting are also discussed. Drug-drug interactions and the effect of nonpharmacological interventions such as renal replacement therapy, plasma exchange, and extracorporeal membrane oxygenation on anticonvulsant removal are also included. Optimal management of antiepileptic drugs in the intensive care unit is challenging given altered physiology, polypharmacy, and nonpharmacological interventions, and requires a multidisciplinary approach where appropriate and timely assessment, diagnosis, treatment, and monitoring plans are in place.

Twitter Demographics

The data shown below were collected from the profiles of 163 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 228 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 11%
Other 25 11%
Student > Master 23 10%
Student > Bachelor 23 10%
Student > Postgraduate 22 10%
Other 68 30%
Unknown 41 18%
Readers by discipline Count As %
Medicine and Dentistry 116 51%
Pharmacology, Toxicology and Pharmaceutical Science 23 10%
Neuroscience 12 5%
Nursing and Health Professions 6 3%
Unspecified 3 1%
Other 15 7%
Unknown 53 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 97. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2021.
All research outputs
#329,763
of 21,376,549 outputs
Outputs from Critical Care
#197
of 5,818 outputs
Outputs of similar age
#8,513
of 298,732 outputs
Outputs of similar age from Critical Care
#1
of 1 outputs
Altmetric has tracked 21,376,549 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,732 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them