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Mortality and associated factors of patients with extensive drug-resistant tuberculosis: an emerging public health crisis in China

Overview of attention for article published in BMC Infectious Diseases, June 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

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1 news outlet
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6 X users

Citations

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15 Dimensions

Readers on

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140 Mendeley
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Title
Mortality and associated factors of patients with extensive drug-resistant tuberculosis: an emerging public health crisis in China
Published in
BMC Infectious Diseases, June 2018
DOI 10.1186/s12879-018-3169-7
Pubmed ID
Authors

Chengli Bei, Manjiao Fu, Yao Zhang, Hebin Xie, Ke Yin, Yanke Liu, Li Zhang, Bangruan Xie, Fang Li, Hua Huang, Yuhong Liu, Li Yang, Jing Zhou

Abstract

Limited treatment options of extensive drug-resistant tuberculosis (XDR-TB) have led to its high mortality worldwide. Relevant data about mortality of XDR-TB patients in literature are limited and likely underestimate the real situation in China, since the majority of patients with XDR-TB are lost to follow-up after discharge from TB hospitals. In this study, we sought to investigate the mortality and associated risk factors of Human Immunodeficiency Virus (HIV)-negative patients with XDR-TB in China. All patients who were diagnosed with XDR-TB for the first time in four TB care centers across China between March 2013 and February 2015 were consecutively enrolled. Active tracking through contacting patients or family members by phone or home visit was conducted to obtain patients' survival information by February 2017. Multivariable Cox regression models were used to evaluate factors associated with mortality. Among 67 patients enrolled, the mean age was 48.7 (Standard Deviation [SD] = 16.7) years, and 51 (76%) were men. Fourteen patients (21%) were treatment naïve at diagnosis indicating primary transmission. 58 (86.8%) patients remained positive for sputum smear or culture when discharged. During a median follow-up period of 32 months, 20 deaths occurred, with an overall mortality of 128 per 1000 person-years. Among patients who were dead, the median survival was 5.4 months (interquartile range [IQR]: 2.2-17.8). Seventeen (85%) of them died at home, among whom the median interval from discharge to death was 8.4 months (IQR: 2.0-18.2). In Cox proportional hazards regression models, body mass index (BMI) < 18.5 kg/m2 (adjusted hazard ratio [aHR] = 4.5, 95% confidence interval [CI]: 1.3-15.7), smoking (aHR = 4.7, 95%CI:1.7-13.2), or a clinically significant comorbidity including heart, lung, liver, or renal disorders or auto-immune diseases (aHR = 3.5, 95%CI: 1.3-9.4), were factors independently associated with increased mortality. Our study suggested an alarming situation of XDR-TB patients in China with a sizable proportion of newly transmitted cases, a high mortality rate, and a long period in community. This observation calls for urgent actions to improve XDR-TB case management in China, including providing regimens with high chances of cure and palliative care, and enhanced infection control measures.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 140 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 14%
Student > Bachelor 17 12%
Researcher 10 7%
Student > Ph. D. Student 10 7%
Student > Doctoral Student 7 5%
Other 26 19%
Unknown 50 36%
Readers by discipline Count As %
Medicine and Dentistry 30 21%
Nursing and Health Professions 16 11%
Biochemistry, Genetics and Molecular Biology 9 6%
Immunology and Microbiology 5 4%
Psychology 4 3%
Other 17 12%
Unknown 59 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2018.
All research outputs
#2,645,593
of 23,088,369 outputs
Outputs from BMC Infectious Diseases
#810
of 7,748 outputs
Outputs of similar age
#56,505
of 329,367 outputs
Outputs of similar age from BMC Infectious Diseases
#21
of 135 outputs
Altmetric has tracked 23,088,369 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,748 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,367 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.