Title |
mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance
|
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Published in |
Critical Care, October 2011
|
DOI | 10.1186/cc10513 |
Pubmed ID | |
Authors |
Fanny Turrel-Davin, Fabienne Venet, Cécile Monnin, Véronique Barbalat, Elisabeth Cerrato, Alexandre Pachot, Alain Lepape, Christine Alberti-Segui, Guillaume Monneret |
Abstract |
It is now well accepted that sepsis is associated with the development of a pronounced immunosuppressive state, characterized by severe immune alterations (e.g. reduced proliferative capacity, endotoxin tolerance, apoptosis) participating in increased mortality and susceptibility to nosocomial infections. Efforts are currently aimed at restoring a functional immune response in septic patients. Successful therapy depends on the identification of appropriate immunostimulatory drugs and on the development of suitable biomarkers that could be used to stratify patients and to follow response to treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 22% |
Researcher | 5 | 14% |
Professor > Associate Professor | 4 | 11% |
Student > Bachelor | 3 | 8% |
Student > Master | 3 | 8% |
Other | 8 | 22% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 33% |
Agricultural and Biological Sciences | 7 | 19% |
Nursing and Health Professions | 4 | 11% |
Immunology and Microbiology | 3 | 8% |
Mathematics | 1 | 3% |
Other | 4 | 11% |
Unknown | 5 | 14% |