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Differential responses of stressful elements to predatory exposure in behavior-lateralized mice

Overview of attention for article published in Behavioral and Brain Functions, June 2018
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Title
Differential responses of stressful elements to predatory exposure in behavior-lateralized mice
Published in
Behavioral and Brain Functions, June 2018
DOI 10.1186/s12993-018-0144-9
Pubmed ID
Authors

Jiacai Yang, Lin Zhang, Jian-ping Dai, Jun Zeng, Xiao-xuan Chen, Ze-feng Xie, Kang-sheng Li, Yun Su

Abstract

Predatory stress as a psychological stressor can elicit the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the dialogue of the neuroimmunoendocrine network. The brain has been proven to regulate the activity of the HPA axis by way of lateralization. In the present study, we probed the pivotal elements of the HPA circuitry including CRH, GR and a multifunctional cytokine in behavior-lateralized mice to determine their changes when the animals were subjected to predator exposure. Behavior-lateralized mice were classified into left-pawed and right-pawed mice through a paw-preference test. Thereafter, mice in the acute stress group received a single 60-min cat exposure, and mice in the chronic group received daily 60-min cat exposure for 14 consecutive days. The plasma CS and TNF-α were determined by ELISA, the hypothalamic CRH mRNA and hippocampal GR mRNA were detected by real-time PCR, and the hippocampal GR protein was detected by western blot analysis. The results revealed that the levels of plasma CS were significantly elevated after chronic predatory exposure in both right-pawed and left-pawed mice; the right-pawed mice exhibited a higher plasma CS level than the left-pawed mice. Similarly, the acute or chronic cat exposure could induce the release of plasma TNF-α, and the left-pawed mice tended to show a higher level after the acute stress. Chronic stress significantly upregulated the expression of hypothalamic CRH mRNA in both left-pawed and right-pawed mice. Normally, the left-pawed mice exhibited a higher GR expression in the hippocampus than the right-pawed mice. After the cat exposure, the expression of GR in both left-pawed and right-pawed mice was revealed to be greatly downregulated. Our findings indicate that predatory stress can invoke a differential response of stressful elements in behavior-lateralized mice. Some of these responses shaped by behavioral lateralization might be helpful for facilitating adaption to various stimuli.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 41%
Student > Bachelor 2 12%
Student > Master 2 12%
Professor 1 6%
Researcher 1 6%
Other 0 0%
Unknown 4 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 18%
Arts and Humanities 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Veterinary Science and Veterinary Medicine 1 6%
Nursing and Health Professions 1 6%
Other 3 18%
Unknown 7 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2018.
All research outputs
#18,637,483
of 23,088,369 outputs
Outputs from Behavioral and Brain Functions
#288
of 392 outputs
Outputs of similar age
#254,227
of 328,957 outputs
Outputs of similar age from Behavioral and Brain Functions
#6
of 6 outputs
Altmetric has tracked 23,088,369 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 392 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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