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Genome-wide mapping of promoter-anchored interactions with close to single-enhancer resolution

Overview of attention for article published in Genome Biology, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

twitter
33 X users
patent
1 patent
wikipedia
1 Wikipedia page

Citations

dimensions_citation
108 Dimensions

Readers on

mendeley
247 Mendeley
citeulike
6 CiteULike
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Title
Genome-wide mapping of promoter-anchored interactions with close to single-enhancer resolution
Published in
Genome Biology, August 2015
DOI 10.1186/s13059-015-0727-9
Pubmed ID
Authors

Pelin Sahlén, Ilgar Abdullayev, Daniel Ramsköld, Liudmila Matskova, Nemanja Rilakovic, Britta Lötstedt, Thomas J. Albert, Joakim Lundeberg, Rickard Sandberg

Abstract

Although the locations of promoters and enhancers have been identified in several cell types, we still have limited information on their connectivity. We developed HiCap, which combines a 4-cutter restriction enzyme Hi-C with sequence capture of promoter regions. Applying the method to mouse embryonic stem cells (mESCs), we identified promoter-anchored interactions involving 15,905 promoters and 71,984 distal regions. The distal regions were enriched for enhancer marks and transcription, and had a mean fragment size of only 699 bp - close to single-enhancer resolution. High-resolution maps of promoter-anchored interactions with HiCap will be important for detailed characterizations of chromatin interaction landscapes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 3 1%
United Kingdom 2 <1%
Hungary 1 <1%
Portugal 1 <1%
Sweden 1 <1%
France 1 <1%
Switzerland 1 <1%
China 1 <1%
Denmark 1 <1%
Other 2 <1%
Unknown 233 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 69 28%
Researcher 61 25%
Student > Bachelor 24 10%
Student > Master 19 8%
Student > Doctoral Student 13 5%
Other 29 12%
Unknown 32 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 112 45%
Biochemistry, Genetics and Molecular Biology 70 28%
Computer Science 12 5%
Medicine and Dentistry 5 2%
Immunology and Microbiology 4 2%
Other 13 5%
Unknown 31 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2020.
All research outputs
#1,654,157
of 25,374,647 outputs
Outputs from Genome Biology
#1,358
of 4,467 outputs
Outputs of similar age
#20,821
of 275,745 outputs
Outputs of similar age from Genome Biology
#31
of 69 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.