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Age-associated reduction of cell spreading induces mitochondrial DNA common deletion by oxidative stress in human skin dermal fibroblasts: implication for human skin connective tissue aging

Overview of attention for article published in Journal of Biomedical Science, July 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#15 of 298)
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

blogs
1 blog
facebook
1 Facebook page

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
65 Mendeley
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Title
Age-associated reduction of cell spreading induces mitochondrial DNA common deletion by oxidative stress in human skin dermal fibroblasts: implication for human skin connective tissue aging
Published in
Journal of Biomedical Science, July 2015
DOI 10.1186/s12929-015-0167-6
Pubmed ID
Authors

Chunji Quan, Moon Kyun Cho, Daniel Perry, Taihao Quan

Abstract

Reduced cell spreading is a prominent feature of aged dermal fibroblasts in human skin in vivo. Mitochondrial DNA (mtDNA) common deletion has been reported to play a role in the human aging process, however the relationship between age-related reduced cell spreading and mtDNA common deletion has not yet been reported. To examine mtDNA common deletion in the dermis of aged human skin, the epidermis was removed from full-thickness human skin samples using cryostat. mtDNA common deletion was significantly elevated in the dermis of both naturally aged and photoaged human skin in vivo. To examine the relationship between age-related reduced cell spreading and mtDNA common deletion, we modulated the shape of dermal fibroblasts by disrupting the actin cytoskeleton. Reduced cell spreading was associated with a higher level of mtDNA common deletion and was also accompanied by elevated levels of endogenous reactive oxygen species (ROS). Boosting cellular antioxidant capacity by using antioxidants was found to be protective against mtDNA common deletion associated with reduced cell spreading. mtDNA common deletion is highly prevalent in the dermis of both naturally aged and photoaged human skin in vivo. mtDNA common deletion in response to reduced cell spreading is mediated, at least in part, by elevated oxidative stress in human dermal fibroblasts. These data extend current understanding of the mitochondrial theory of aging by identifying the connection between mtDNA common deletion and age-related reduction of cell spreading.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 20%
Researcher 11 17%
Student > Ph. D. Student 6 9%
Student > Bachelor 6 9%
Other 5 8%
Other 11 17%
Unknown 13 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 18%
Agricultural and Biological Sciences 10 15%
Medicine and Dentistry 9 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Nursing and Health Professions 3 5%
Other 11 17%
Unknown 16 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2015.
All research outputs
#653,116
of 5,436,647 outputs
Outputs from Journal of Biomedical Science
#15
of 298 outputs
Outputs of similar age
#31,711
of 189,787 outputs
Outputs of similar age from Journal of Biomedical Science
#2
of 19 outputs
Altmetric has tracked 5,436,647 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 298 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,787 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.