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Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013

Overview of attention for article published in BMC Infectious Diseases, June 2018
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Title
Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013
Published in
BMC Infectious Diseases, June 2018
DOI 10.1186/s12879-018-3177-7
Pubmed ID
Authors

Ki Wook Yun, Eun Hwa Choi, Hoan Jong Lee, Jin Han Kang, Kyung-Hyo Kim, Dong Soo Kim, Yae-Jean Kim, Byung Wook Eun, Sung Hee Oh, Hye-Kyung Cho, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun-Kyung Kim, Hyunju Lee, Taekjin Lee, Hwang Min Kim, Eun Young Cho, Chun Soo Kim, Su Eun Park, Chi Eun Oh, Dae Sun Jo, Young Youn Choi, Jina Lee

Abstract

Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of invasive pneumococcal isolates obtained from children before and after the use of pneumococcal conjugate vaccines (PCVs) in Korea. A total of 285 invasive pneumococcal isolates were analyzed using serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. We classified the isolation year to pre-PCV7 (1995-2003; n = 70), post-PCV7 (2004-2010; n = 142), and post-PCV13 (2011-2013; n = 73) periods. Of the 10 clonal complexes (CCs), antibiotic-resistant international clones, CC320 (31.6%), CC81 (14.7%), and CC166 (6.7%) were the main complexes. Serotype 19A was the main serotype of CC320 throughout the periods. Serotypes of CC81 mainly comprised of 23F (53.3%) in pre-PCV7 period and replaced by non-vaccine types (NVTs; 6C [10%], 13 [30%], 15A [40%], and 15B/C [20%]) in post-PCV13 period. The main serotype responsible for CC166 also changed from 9 V (80%) in pre-PCV7 to NVT 11A (50%) in post-PCV13 periods. Non-susceptibility to penicillin (42.3%) was the highest in CC320, increasing from 0 to 76%. The genetic structures of invasive pneumococcal isolates in Korean children have changed concomitantly with serotype after the implementation of PCVs.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 11%
Researcher 5 11%
Other 4 9%
Student > Master 4 9%
Student > Postgraduate 3 7%
Other 9 20%
Unknown 14 32%
Readers by discipline Count As %
Medicine and Dentistry 13 30%
Immunology and Microbiology 6 14%
Biochemistry, Genetics and Molecular Biology 3 7%
Nursing and Health Professions 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 1 2%
Unknown 18 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2018.
All research outputs
#20,520,426
of 23,090,520 outputs
Outputs from BMC Infectious Diseases
#6,539
of 7,748 outputs
Outputs of similar age
#288,643
of 328,957 outputs
Outputs of similar age from BMC Infectious Diseases
#112
of 135 outputs
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