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Procalcitonin-guided antibiotic therapy for septic patients in the surgical intensive care unit

Overview of attention for article published in Journal of Intensive Care, August 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 544)
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

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78 X users
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3 Facebook pages

Citations

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22 Dimensions

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94 Mendeley
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Title
Procalcitonin-guided antibiotic therapy for septic patients in the surgical intensive care unit
Published in
Journal of Intensive Care, August 2015
DOI 10.1186/s40560-015-0100-9
Pubmed ID
Authors

John Alfred Carr

Abstract

In critically ill patients, elucidating those patients with the systemic inflammatory response syndrome (SIRS) from an infectious source (sepsis), versus those who have SIRS without infection, can be challenging since the clinical features are the same. Even with strict monitoring and testing, 39-98 % of patients with SIRS will never have bacteriological confirmation of an infection, and 6-17 % of patients with a documented infection will not show signs of SIRS. Due to this overlap, an extensive amount of research has been performed to investigate ways of determining and separating SIRS from infection, compared to SIRS due to trauma, surgical stress, or other non-infectious causes. This review article will discuss the recommended and peer-approved use of procalcitonin in septic patients in the intensive care unit and its use as a guide to antibiotic initiation and termination. The article will focus on the prospective randomized trials (Level 1 evidence) that have been conducted, and lesser levels of evidence will be referenced as needed to substantiate a conclusion. The literature documents multiple benefits of using procalcitonin as a guide to cost savings and appropriate termination of antibiotics by its use as a new objective marker of bacteremia that was previously not available. This article will show that antibiotics should be terminated when the procalcitonin level falls below 0.5 ng/mL.

X Demographics

X Demographics

The data shown below were collected from the profiles of 78 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
United States 1 1%
Unknown 92 98%

Demographic breakdown

Readers by professional status Count As %
Other 15 16%
Student > Master 12 13%
Student > Postgraduate 10 11%
Student > Doctoral Student 10 11%
Professor > Associate Professor 7 7%
Other 24 26%
Unknown 16 17%
Readers by discipline Count As %
Medicine and Dentistry 60 64%
Engineering 4 4%
Immunology and Microbiology 2 2%
Agricultural and Biological Sciences 2 2%
Economics, Econometrics and Finance 1 1%
Other 4 4%
Unknown 21 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2019.
All research outputs
#833,631
of 24,163,421 outputs
Outputs from Journal of Intensive Care
#31
of 544 outputs
Outputs of similar age
#10,745
of 268,491 outputs
Outputs of similar age from Journal of Intensive Care
#2
of 10 outputs
Altmetric has tracked 24,163,421 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 544 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,491 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.