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Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization

Overview of attention for article published in Clinical Epigenetics, June 2017
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Title
Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization
Published in
Clinical Epigenetics, June 2017
DOI 10.1186/s13148-017-0361-3
Pubmed ID
Authors

Kyung Hwa Jung, Stephanie Lovinsky-Desir, Beizhan Yan, David Torrone, Jennifer Lawrence, Jacqueline R. Jezioro, Matthew Perzanowski, Frederica P. Perera, Steven N. Chillrud, Rachel L. Miller

Abstract

Asthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not been fully elucidated. Our objective was to determine the timeline of black carbon (BC) exposure, measured by personal sampling, on DNA methylation of allergic asthma genes 5 days later to capture usual weather variations and differences related to changes in behavior and activities. We also sought to determine how methylation may vary by seroatopy and cockroach sensitization and by elevated fractional exhaled nitric oxide (FeNO). Personal BC levels were measured during two 24-h periods over a 6-day sampling period in 163 New York City children (age 9-14 years), repeated 6 months later. During home visits, buccal cells were collected as noninvasive surrogates for lower airway epithelial cells and FeNO measured as an indicator of airway inflammation. CpG promoter loci of allergic asthma genes (e.g., interleukin 4 (IL4), interferon gamma (IFNγ), inducible nitric oxide synthase (NOS2A)), arginase 2 (ARG2)) were pyrosequenced at the start and end of each sampling period. Higher levels of BC were associated with lower methylation of IL4 promoter CpG(-48) 5 days later. The magnitude of association between BC exposure and demethylation of IL4 CpG(-48) and NOS2A CpG(+5099) measured 5 days later appeared to be greater among seroatopic children, especially those sensitized to cockroach allergens (RR [95% CI] 0.55 [0.37-0.82] and 0.67 [0.45-0.98] for IL4 CpG(-48) and NOS2A CpG(+5099), respectively), compared to non-sensitized children (RR [95% CI] 0.87 [0.65-1.17] and 0.95 [0.69-1.33] for IL4 CpG(-48) and NOS2A CpG(+5099), respectively); however, the difference was not statistically different. In multivariable linear regression models, lower DNA methylation of IL4 CpG(-48) and NOS2A CpG(+5099) were associated with increased FeNO. Our results suggest that exposure to BC may exert asthma proinflammatory gene demethylation 5 days later that in turn may link to airway inflammation. Our results further suggest that seroatopic children, especially those sensitized to cockroach allergens, may be more susceptible to the effect of acute BC exposure on epigenetic changes.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 20%
Student > Master 10 18%
Researcher 8 14%
Student > Bachelor 6 11%
Student > Postgraduate 3 5%
Other 9 16%
Unknown 9 16%
Readers by discipline Count As %
Medicine and Dentistry 13 23%
Environmental Science 8 14%
Nursing and Health Professions 6 11%
Engineering 5 9%
Biochemistry, Genetics and Molecular Biology 4 7%
Other 9 16%
Unknown 11 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2018.
All research outputs
#8,305,347
of 13,780,426 outputs
Outputs from Clinical Epigenetics
#466
of 684 outputs
Outputs of similar age
#152,348
of 270,743 outputs
Outputs of similar age from Clinical Epigenetics
#1
of 1 outputs
Altmetric has tracked 13,780,426 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 684 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,743 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them